02285nas a2200229 4500008004100000245012700041210006900168260001800237300001000255490000600265520156500271653002101836653001301857653001201870653001301882653001901895100001801914700001801932700002601950700001601976856006301992 2012 eng d00aEffect of Butea Monosperma Lam. Leaves and Bark Extracts on Blood Glucose in Streptozotocin-induced Severely Diabetic Rats0 aEffect of Butea Monosperma Lam Leaves and Bark Extracts on Blood cdecember,2011 a33-360 v43 a

Background: Diabetes mellitus is a chronic metabolic disorder that has significant impact on the health, quality of life and life expectancy, as well as on the health care system. Butea monosperma Lam. Kuntze (Fabaceae), commonly known as palash, is widely used in the treatment of various diseases and disorders including diabetes. Materials and Methods: The present study was planned to evaluate the antidiabetic effect of aqueous extracts of B. monosperma leaves and bark in streptozotocin-induced severely diabetic rats. The animals were divided into four groups, with each consisting of six rats, viz. control, diabetic control, leaf extract-treated and bark extract-treated groups. Treatment was continued for 6 weeks. The biochemical estimations included blood glucose and serum insulin levels. Histopathology of pancreas was also performed. Results: The results indicated that both leaf and bark extracts of B. monosperma produced insignificant antihyperglycemic activity. The leaf and bark extracts reduced blood glucose to an extent of 28% and 11%, respectively. It was also evidenced that both leaf and bark extracts did not increase insulin synthesis or secretion and did not improve pancreatic architecture as reflected by the histopathologic studies. Conclusions: The findings of the study emphasize that B. monosperma does not possess significant antidiabetic activity in severe experimental diabetes at the dosage tested.

10aButea monosperma10aDiabetes10aInsulin10aPancreas10aStreptozotocin1 aAhmed, Faiyaz1 aSiddaraju, NS1 aHarish, Asna, Urooj M1 aUrooj, Asna uhttps://phcogres.com/article/2012/4/1/1041030974-849091032