02329nas a2200205 4500008004100000245009500041210006900136260001800205300001000223490000600233520168400239653001501923653001201938653002101950653002801971653002401999100001902023700001802042856006302060 2012 eng d00aDichlorvos and Lindane Induced Oxidative Stress in Rat Brain: Protective Effects of Ginger0 aDichlorvos and Lindane Induced Oxidative Stress in Rat Brain Pro cdecember,2011 a27-320 v43 a

Background: Dichlorvos and lindane pesticide causes toxicity in animals including humans. Ginger (Zingiber officinale) is widely used as a culinary medicine in the Ayurvedic system of medicine, possessing a number of pharmacological properties. Objective: This study was designed to assess ameliorating effects of ginger juice in dichlorvos and lindane induced neurotoxicity in wistar rats. Materials and Methods: Dichlorvos (8.8 mg/kg bw) and lindane (8.8 mg/kg bw) were orally administered alone as well as in combination to adult male and female wistar rats for 14 days followed by the post-treatment of ginger juice (100 mg/kg bw) for 14 days. Lipid peroxidation (LPO), reduced glutathione (GSH), and activities of antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione S-transferase (GST), glutathione reductase (GR), quinine reductase (QR), and protein level were measured to evaluate the toxicity of these pesticides in brain. Results: Dichlorvos and lindane administration alone and in combination increased LPO and decreased the GSH level, SOD, CAT, GPx, GST, GR, QR activity, and protein. Oxidative stress due to abnormal production of reactive oxygen species (ROS) is believed to be involved in the toxicities induced by these pesticides. Post-treatment of ginger juice decreased LPO and increased the level of GSH, SOD, CAT, GPx, GST, GR, QR activity and protein in the brain of rats. Conclusions: The results indicated that dichlorovos and lindane induced tissue damage was ameliorated by ginger juice.

10aDichlorvos10aLindane10aOxidative stress10aReactive oxygen species10aZingiber officinale1 aSharma, Poonam1 aSingh, Rambir uhttps://phcogres.com/article/2012/4/1/1041030974-849091031