02274nas a2200217 4500008004100000245009800041210006900139260001300208300001300221490000600234520158300240653002301823653002101846653000801867653002001875653002401895100002101919700002801940700002401968856006401992 2013 eng d00aProtective Effects of Vernonia Amygdalina Against Sodium Arsenite-induced Genotoxicity in Rat0 aProtective Effects of Vernonia Amygdalina Against Sodium Arsenit cMay 2013 a 207-2110 v53 a

Objectives: Contamination of the environment with arsenic (As) from both human and natural sources is known as a global problem. This study investigated the chemoprotective potential of Vernonia amygdalina leave extract against sodium arsenite-induced genotoxicity and hepatotoxicity. Materials and Methods : Genotoxic effects were evaluated in the rat bone marrow using micronuclei. The gamma glutamyl transpeptidase (GGT) and alkaline phosphatase (ALP) activities were assayed in rat serum. Results : Pre-treatment with extract of V. amygdalina at doses 5 mg/kg and 10 mg/kg significantly decreased the frequency of micronucleated polychromatic erythrocytes (PCEs). The GGT and ALP activities were elevated more than fourfold, in the liver of rats treated with sodium arsenite, while it was reduced almost to half when the sodium arsenit-treated rats were fed fresh V. amgdalina leave extracts The phytochemical constituents of V. amygdalina assayed in this study may be responsible for high radical scavenging of the DPPH free radical observed. Conclusion : The present results indicate that V. amygdalina extract is capable of suppressing the chromosomal aberration induced by sodium arsenite in rat. Thus, V. amygdalina may be a potent chemoprotective agent against the toxicity of sodium arsenite in rats.

10aAnticlastogenicity10aMicronuclei Test10aRat10aSodium arsenite10aVernonia amygdalina1 aAdetutu, Adewale1 aOyewo, Emmanuel, Bukoye1 aAdesokan, Ayoade, A uhttps://phcogres.com/article/2013/5/3/1041030974-8490112431