02906nas a2200301 4500008004100000245011900041210006900160260001500229300001000244490000600254520196200260653001802222653002002240653002602260653002202286653001102308653002402319100002502343700001802368700002402386700002402410700002002434700002502454700001802479700002202497700002202519856006302541 2012 eng d00aEffects of Cinnamomum zeylanicum (Ceylon cinnamon) on blood glucose and lipids in a diabetic and healthy rat model0 aEffects of Cinnamomum zeylanicum Ceylon cinnamon on blood glucos capril,2012 a73-790 v43 a

Objectives: To evaluate short- and long-term effects of Cinnamomum zeylanicum on food consumption, body weight, glycemic control, and lipids in healthy and diabetes-induced rats. Materials and Methods: The study was conducted in two phases (Phase I and Phase II), using Sprague-Dawley rats in four groups. Phase I evaluated acute effects on fasting blood glucose (FBG) (Groups 1 and 2) and on post-oral glucose (Groups 3 and 4) blood glucose. Groups 1 and 3 received distilled-water and Groups 2 and 4 received cinnamon-extracts. Phase II evaluated effects on food consumption, body weight, blood glucose, and lipids over 1 month. Group A (n = 8, distilled-water) and Group B (n = 8, cinnamon-extracts) were healthy rats, while Group C (n = 5, distilled-water) and Group D (n = 5, cinnamon-extracts) were diabetes-induced rats. Serum lipid profile and HbA1c were measured on D-0 and D-30. FBG, 2-h post-prandial blood glucose, body weight, and food consumption were measured on every fifth day. Results: Phase I: There was no significant difference in serial blood glucose values in cinnamon-treated group from time 0 (P > 0.05). Following oral glucose, the cinnamon group demonstrated a faster decline in blood glucose compared to controls (P < 0.05). Phase II: Between D0 and D30, the difference in food consumption was shown only in diabetes-induced rats (P < 0.001). Similarly, the significant difference following cinnamon-extracts in FBG and 2-h post-prandial blood glucose from D0 to D30 was shown only in diabetes-induced rats. In cinnamon-extracts administered groups, total and LDL cholesterol levels were lower on D30 in both healthy and diabetes-induced animals (P < 0.001). Conclusions: C. zeylanicum lowered blood glucose, reduced food intake, and improved lipid parameters in diabetes-induced rats.

10aBlood glucose10aCeylon cinnamon10aCinnamomum zeylanicum10aDiabetes mellitus10aLipids10aSprague-Dawley rats1 aRanasinghe, Priyanga1 aPerera, Sanja1 aGunatilake, Mangala1 aAbeywardene, Eranga1 aGunapala, Nuwan1 aPremakumara, Sirimal1 aPerera, Kamal1 aLokuhetty, Dilani1 aKatulanda, Prasad uhttps://phcogres.com/article/2012/4/2/1041030974-849094719