02317nas a2200241 4500008004100000245011300041210006900154260001800223300001200241490000600253520153800259653001801797653004101815653001801856653002801874100002001902700002101922700002301943700001301966700001601979700001601995856006402011 2012 eng d00aPreliminary Phytochemical and Antibacterial Screening of Sesuvium Portulacastrum in the United Arab Emirates0 aPreliminary Phytochemical and Antibacterial Screening of Sesuviu cOctober ,2012 a219-2240 v43 a

Background: The present study describes the phytochemical profile and antimicrobial activity of Sesuvium portulacastrum. Materials and Methods: Three extracts of S. portulacastrum obtained by extraction in aqueous, ethanolic and dichloromethane solvents, respectively, were compared for their antimicrobial activity and ethanolic extract further subjected to gas chromatography-mass spectrometry (GC-MS) analysis to find out the nature of the compounds responsible for the antimicrobial activity. The antibacterial activities were assessed by measuring the diameter of the inhibition zones, minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values. Results: Compared to the aqueous and dichloromethane extract, the ethanolic extract showed better antimicrobial activity against Staphylococcus aureus and E. coli, indicating its potential application related to noscomial infections. GC-MS results revealed 22, 23-Dihydrostigmasterol, Benzoic acid, 3,4,5-trihydroxy-(Gallic acid), (2R,3R)-(-)-Epicatechin and Capsaicin in the ethanolic extract to be the molecules responsible for the antimicrobial activity of S. portulacastrum. Conclusion: To the best of our knowledge, this is the first report on analysis of antimicrobial components from S. portulacastrum in United Arab Emirates (UAE), and our results confer the utility of this plant extract in developing a novel broad spectrum antimicrobial agent.

10aAntibacterial10aGas chromatography-mass spectrometry10aPhytochemical10aSesuvium portulacastrum1 aAl-Azzawi, Amad1 aAlguboori, Alyaa1 aHachim, Mahmoud, Y1 aNajat, M1 aShaimaa, Al1 aSad, Maryam uhttps://phcogres.com/article/2012/4/4/1041030974-8490102269