02418nas a2200289 4500008004100000245013700041210006900178260001800247300001200265490000600277520153100283653001701814653001201831653001701843653000901860653001001869653001601879100002901895700002701924700001901951700001601970700002101986700001602007700002002023700002102043856006402064 2012 eng d00aComparative Analysis on the Effect of Palm Oil (Elaeis guineensis) in Reducing Cadmium and Lead Accumulation in Liver of Wistar Rats0 aComparative Analysis on the Effect of Palm Oil Elaeis guineensis cOctober ,2012 a214-2180 v43 a

Context: Palm oil from Elaeis guineensis is an edible nutrient substance with anti-inflammatory and antioxidant properties. We examined its protective effect against lead (Pb) and cadmium (Cd) accumulation in the liver. Materials and Methods: 12% w/w of palm oil (PO) in rat chow concentrate was fed to rats exposed to Cd (200ppm) and Pb (100ppm) in drinking water at different feeding regimens. PO was administered either at the same time with the metals (group 2), post-treatment after exposure (group 3) or pre-treatment before exposure (group 4) for six weeks. The heavy metal accumulations in the liver were determined using AAS. Results: Weight losses induced by these metals were significantly (P<0.05) reversed by PO administration. Analysis among the groups showed that post-treatment group had a significant (P<0.05) higher percentage protection to Cd, but same time treatment for Pb (P<0.05) when compared with other groups. The protective ability to PO was only significantly (P<0.05) increased for Pb at week 2, but showed a time-dependent significant (P<0.05) increase for Cd across all treatment regimens. Conclusion: PO is beneficial in reducing metal accumulation in the liver and has a higher hepatoprotective effect to Cd compared to Pb at the selected doses by possibly affecting the processes of uptake, assimilation and elimination of these metals.

10aAccumulation10aCadmium10aHeavy metals10aLead10aLiver10aProtection.1 aNwokocha, Chukwuemeka, R1 aNwokocha, Magdalene, I1 aOwu, Daniel, U1 aObi, Joshua1 aOlatunde, Bukola1 aEbe, Chioma1 aNwangwu, Ozioma1 aIwuala, Moses, O uhttps://phcogres.com/article/2012/4/4/1041030974-8490102266