02619nas a2200193 4500008004100000245009900041210006900140260001600209300001200225490000600237520194700243653002902190653006202219653001702281100002602298700001902324700001802343856006402361 2013 eng d00aAnti-inflammatory and Anti-hyperalgesic Activities of Acanthopanax Trifoliatus (L) Merr Leaves0 aAntiinflammatory and Antihyperalgesic Activities of Acanthopanax cApril 2013 a129-1330 v53 a

Context: Acanthopanax trifoliatus is a ginseng-like plant, which has been widely used to treat various diseases including inflammatory-related diseases. Aims: The present study has been designed to investigate the anti-inflammatory and anti-hyperalgesic effects of various fractions of Acanthopanax trifoliatus leaves ethanolic extract in rats. Materials and Methods: Anti-inflammatory activity was studied by using carrageenan-induced edema on rat paw whilst anti-hyperalgesic was assessed by using carrageenan-evoked thermal hyperalgesia on plantar test. Statistical Analysis Used: Data were analyzed using Student t-test to compare with control.Multiple comparisons for difference between control and extract-treated groups were evaluated by Tukey HSD (Honestly Significant Difference) test. P values less than 0.05 (P < 0.05) is considered significant. Results: Among three different fractions i.e., hexane, dichloromethane, and methanol tested, methanolic fraction displayed the most potent fraction amongst those three. It gave significant anti-inflammatory effect at highest dose, 500 mg/kg, with 77.24% of inhibition. Whilst for anti-hyperalgesic activity, methanolic fraction showed the highest efficacy at 375 mg/kg. Administration of methanolic fraction of Acanthopanax trifoliatus inhibited paw edema in a dose- dependent manner. The inhibition for both activities might be due to possible composition of polar compounds, which are flavonoids and phenolics content. Conclusions: Methanol fraction of Acanthopanax trifoliatus leaves has potential effect as anti-inflammatory and anti-hyperalgesia in acute inflammation model.

10aAcanthopanax Trifoliatus10aAnti-hyperalgesic Carrageenan-evoked Thermal Hyperalgesia10aPlantar Test1 aHamid, Roslida, Abdul1 aKee, Teoh, Hui1 aOthman, Fezah uhttps://phcogres.com/article/2013/5/2/1041030974-8490110544