02811nas a2200229 4500008004100000245010600041210006900147260001600216300001200232490000600244520205600250653002802306653002702334653003302361653001902394653002102413100002102434700002202455700002102477700001902498856006402517 2013 eng d00aAnti-arthritic Activity of Root Bark of Oroxylum Indicum (L.) Vent Against Adjuvant-induced Arthritis0 aAntiarthritic Activity of Root Bark of Oroxylum Indicum L Vent A cApril 2013 a121-1280 v53 a

Background: Oroxylum indicum (Bignoniaceae) also known as Sonapatha is an indigenous medicinal plant widely used in Ayurvedic medicine for over thousands of years. It is an active ingredient of well-known Ayurvedic formulations such as Chyawanprash and Dasamula. Root bark of this plant has tonic and astringent properties and it is also used in rheumatism. Objective: The present investigation was carried out to evaluate the anti-arthritic activity of different extracts of root bark of Oroxylum indicum against adjuvant - induced arthritis in rats. Materials and Methods: Male Wistar rats were used in this study. Arthritis was induced by injecting 0.1 ml Freund's complete adjuvant intra-dermally into the left hind paw of the rats. The paw volume, hematological, biochemical, radiographic and histopathological aspects were evaluated. Results: The relative percentage inhibition potential of paw volume in rats treated with various extracts of Oroxylum indicum was found to be ethyl acetate extract (67.69%) >chloroform extract (64.61%) >n-butanol extract (58.46%) respectively. The hematological parameters like RBC count, hemoglobin content showed significant increase while there was a significant decrease in total WBC count and ESR in all the groups of animals pretreated with root bark extracts. The biochemical parameters such as catalase, glutathione contents showed a significant increase while the lipid peroxide and Cathepsin-D content decreased significantly only in case of ethyl acetate pretreated rats when compared to others. Conclusion: The present study suggests that the chloroform, ethyl acetate and n-butanol extracts of root bark of Oroxylum indicum exhibit anti-arthritic activity. The order of activity of extracts was found to be ethyl acetate >chloroform >n-butanol respectively.

10aAnti-arthritic Activity10aBiochemical parameters10aFreund′s Complete Adjuvant10aHistopathology10aOroxylum indicum1 aKarnati, Mamatha1 aChandra, Rodda, H1 aVeeresham, Ciddi1 aKishan, Bookya uhttps://phcogres.com/article/2013/5/2/1041030974-8490110543