02292nas a2200229 4500008004100000245013900041210006900180260001700249300000800266490000600274520153000280653001501810653002301825653001001848653002101858653001701879653002001896653002201916100003001938700003001968856006401998 2015 eng d00aThe evaluation of the activity of medicinal remedies of plant and animal origin on the regeneration of the earthworms’ tail segments0 aevaluation of the activity of medicinal remedies of plant and an cOctober 2015 a3930 v73 a

Now, in the global community there is enough hard recommendation to replace the vertebrate test animals into simpler organisms at the development, testing, and evaluation of the quality pharmaceuticals. The feature of planarian to regenerate in new individual planarian from a piece, which is only 1/7 of the original animal, allowed to create the alternative methods of testing of drugs, dietary supplements, water quality, influence of electromagnetic fields, and other radiations. The tests on planarian can replace the ones that are held today on mammals. However, the lacks of the bioassays based on the planarian regeneration are the need for complex and expensive video equipment for recording the regrowth of worms’ body, the difficulties of culturing of flatworms and fairly long period of response. These difficulties can be avoided by using another group of the worms of type Annelida. The new individual can be fully recovered only from the front half of the body in many species of earthworms. Thus, the influence of the pharmaceuticals from earthworms, mummy, and Orthilia secunda on the ability of earthworms to regenerate lost tail segments has been investigated. The relations of the activity of preparations tested with doses and the time of the storage have been revealed. The principal possibility of applicability of the test reaction studied as a way to evaluate the effects and quality of remedies based on medicinal plants and earthworms has been shown.

10aEarthworms10aMedicinal remedies10aMummy10aOrthilia secunda10aRegeneration10aTest‑reaction10aVermipreparation.1 aBybin, Viktor, Alexandrov1 aStom, Daevard, Iosifovich uhttps://phcogres.com/article/2015/7/4/1041030974-8490159581