02350nas a2200217 4500008004100000245013500041210006900176260001800245300001200263490000600275520162800281653003001909653002101939653002101960653002301981100001702004700001502021700001802036700002102054856005702075 2017 eng d00aPharmacological Screening of Trachyspermum ammi for Antihyperlipidemic Activity in Triton X‑100 Induced Hyperlipidemia Rat Model0 aPharmacological Screening of Trachyspermum ammi for Antihyperlip cDecember 2017 as34-s400 v93 a

Background: Mortality rate is increasing due to cardiovascular problems throughout the world. These cardiac problems are directly associated with dyslipidemia. Aim: The aim of this study was to evaluate the antihyperlipidemic effect of aqueous extract and methanol extract of Trachyspermum ammi at 1 g/kg, 3 g/kg, and 5 g/kg dose levels in rats. Materials and Methods: For this purpose, 45 male albino rats were used and randomly divided into nine equal groups (n = 5). The lipid levels were increased after 24 h of single intraperitoneal injection of Triton X‑100 (100 mg/kg) in rats. Aqueous and methanol extracts equivalent to 1 g/kg, 3 g/kg, and 5 g/kg were administered orally to the rats for 21 days. Atorvastatin (10 mg/kg) was used as standard drug. Blood samples were collected at 0, 2nd, 9th, 16th, and 23rd day by a direct cardiac puncture in Vacuette® heparin tubes. Serum was separated and then analyzed for lipid profile, liver function test (LFT), and renal function test (RFT) using standard diagnostic kits. Results: Results showed that extracts at 3 g/kg and 5 g/kg decreased the levels of total cholesterol, triglyceride, and low‑density lipoprotein and increased high‑density lipoprotein concentration in serum. T. ammi also decreased LFT and RFT parameters at the end of the study. Conclusion: T. ammi possessed antioxidant and antihyperlipidemic activities along with hepato‑ and nephro‑protective effects.

10aAntihyperlipidemic effect10aHepatoprotective10aOxidative stress10aTrachyspermum ammi1 aSaleem, Uzma1 aRiaz, Saba1 aAhmad, Bashir1 aSaleem, Mohammad uhttps://phcogres.com/article/2017/9/5/104103prpr3717