02873nas a2200217 4500008004100000245012200041210006900163260001300232300001000245490000700255520215400262653001302416653002002429653001802449653001902467100001902486700003502505700003202540700002502572856005802597 2021 eng d00aLeaf Extracts of Glyphaea brevis Attenuate High Blood Glucose and Lipids in Diabetic Rats Induced with Streptozotocin0 aLeaf Extracts of Glyphaea brevis Attenuate High Blood Glucose an cMay 2021 a82-880 v133 a

Background: Diabetes is a non-communicable disease causing impairment of carbohydrate and lipid metabolisms. Previous ethnobotanical surveys showed that leaves of Glyphaea brevis (G. brevis) are used conventionally in the treatment of diabetes with limited scientific evidence. Objective: We aimed to determine the effects of aqueous (AE) and hydroethanolic extracts (HEE) of G. brevis leaves in attenuating diabetes-linked hyperglycemia and hyperlipidemia in an animal model. Materials and Methods: Thirty streptozotocin-induced diabetic male rats were divided into six groups receiving the following daily treatments for 4 weeks orally: control (distilled water), reference (tolbutamide 80 mg/kg) and 4 tests (AE 250 mg/kg, AE 500 mg/kg, HEE 250 mg/kg, and HEE 500 mg/kg). The effects of each treatment on postprandial hyperglycemia were assessed using oral glucose tolerance and oral starch tolerance tests. Blood was collected to assess the effects of treatments on fasting plasma glucose, glycated hemoglobin (HbA1c), and lipid profile. Liver glycogen and gluconeogenic enzyme activity were also measured. Results: AE- and HEE-treated rats had 36%–64% lower fasting blood glucose levels, 34%–73% lower postprandial glycemia, and 15%–75% lower HbA1c than rats from control group (P < 0.01). AE and HEE treatments also brought about a significant increase in liver glycogen levels and lower gluconeogenic enzyme activity (P < 0.01). Extract-treated groups also had lower plasma total cholesterol and low-density lipoprotein-cholesterol concentrations (P < 0.01). Conclusion: These results suggest that treatment with leaf extracts of G. brevis is effective in attenuating hyperglycemia and hyperlipidemia in streptozotocin-induced diabetic rats. Future studies will determine the active compounds accountable for these beneficial effects.

10aDiabetes10aGlyphaea brevis10aHyperglycemia10aHyperlipidemia1 aDakam, William1 aBiyegue, Christine, Fernande N1 aFannang, Simone, Véronique1 aOben, Julius, Enyong uhttps://phcogres.com/article/2021/13/2/104103prpr9920