02502nas a2200229 4500008004100000245007300041210006900114260001600183300001200199490000600211520179200217653001502009653001902024653002102043100002202064700002602086700002402112700003002136700001702166700002502183856006402208 2016 eng d00aEffect of Musa sapientum Stem Extract on Animal Models of Depression0 aEffect of Musa sapientum Stem Extract on Animal Models of Depres cAugust 2016 a249-2520 v83 a
Background: Musa sapientum, the banana plant, has shown to possess antioxidant activity in previous studies. Oxidative stress has been linked to the pathogenesis of major depressive disorder (MDD) with evidence of increased serum levels of oxidative stress biomarkers in MDD patients. Objective: The present study aimed to evaluate the antidepressant activity of M. sapientum stem extract (MSSE) in experimental models in mice. Materials and Methods: Forced swim test (FST) and tail suspension test (TST) were carried out in five different groups (n = 6/ group) of mice. The vehicle, standard drug, and the three test groups were orally administered distilled water (10 mL/kg), fluoxetine (25 mg/kg), and incremental doses of 25, 50, and 100 mg of MSSE, respectively, 45 min prior to the experiment. Results: On FST, the duration of immobility in control group, which was 161.5 ± 6.78 (in seconds, mean ± standard error of mean [SEM]), decreased to 149.33 ± 2.70 (25 mg/kg MSSE), 120.17 ± 8.35 (50 mg/kg MSSE), and 45.17 ± 4.11 (100 mg/kg MSSE) in the treated groups. On TST, the duration of immobility in control group, which was 173.83 ± 12.65 (mean ± SEM), decreased to 163.17 ± 6.91 (25 mg/kg MSSE), 139.0 ± 5.9 (50 mg/kg MSSE), and 124.0 ± 4.42 (100 mg/kg MSSE) in the treated groups. The difference in the duration of immobility was statistically significant at middle and higher doses, i.e. 50 and 100 mg/kg MSSE (P < 0.05) respectively, when compared with the control group in both the tests. Conclusion: A significant antidepressant‑like activity was found in MSSE, which could be a potential natural compound for use in depression.
10aDepression10aMusa sapientum10aOxidative stress1 aReddy, Aditya, J.1 aHandu, Shailendra, S.1 aDubey, Ashok, Kumar1 aMediratta, Pramod, Kumari1 aShukla, Rimi1 aAhmed, Qazi, Mushtaq uhttps://phcogres.com/article/2016/8/4/1041030974-8490188876