02624nas a2200217 4500008004100000245008600041210006900127260001600196300001200212490000600224520193400230653001602164653002102180653001602201653002202217653004302239653001402282100002302296700002302319856006402342 2016 eng d00aEvaluation of Antiulcer and Antioxidant Activity of Barleria gibsoni Dalz. Leaves0 aEvaluation of Antiulcer and Antioxidant Activity of Barleria gib cAugust 2016 a226-2300 v83 a

Background: Peptic ulcer is a digestive disorder most commonly found in clinical practice. Given the many side effects of modern medicine, the initial acquisition of fewer side effects, and medication of indigenous drugs, it should be considered as a better alternative for the treatment of peptic ulcer. Objective: To assess antiulcer and antioxidant activity of ethanol extract of Barleria gibsoni (EBG) Dalz. leaves in ulcer‑induced rats and in vitro antioxidants method, respectively. Materials and Methods: Ethanol EBG was screened for antiulcer activity in pylorus ligation‑induced ulcer models in Wistar rats. In vitro antioxidant activity of the extracts was tested using 2,2‑diphenyl‑1‑picrylhydrazyl (DPPH), nitric oxide (NO) radical scavenging activity. Total phenol and flavonoid content in the extracts were determined spectrophotometrically. Results: Oral administration of ethanol extract of leaves at doses of 250, 500 mg/kg p.o. reduced significant gastric lesions induced by pylorus ligation‑induced ulcer as compared to standard omeprazole (20 mg/kg p.o.). The IC50 values were found to be 150 μg/mL in leaves extract. The ethanol extracts showed good antioxidant capacity in DPPH radical scavenging assay and NO radical scavenging activity when compared to standard. The total phenolic content using Folin–Ciocalteu reagent estimated in 1 mg of leaves extracts was 368 μg and 481 μg with gallic acid equivalent and also the total flavonoid content found to be 240 and 410 μg, respectively, with quercetin equivalence. Conclusion: These findings suggest that the leaves of B. gibsoni possessed antiulcer potential and antioxidant compared to standard. This is the first ever report of antiulcer and antioxidant activities in B. gibsoni (Acanthaceae).

10aAcanthaceae10aBarleria gibsoni10aGallic acid10aL‑ascorbic acid10aPylorus ligation‑induced ulcer model10aQuercetin1 aTamboli, Firoj, A.1 aMore, Harinath, N. uhttps://phcogres.com/article/2016/8/4/1041030974-8490188879