02704nas a2200265 4500008004100000245007700041210006900118260001500187300001000202490000600212520190700218653002402125653001702149653001202166653001202178653002702190653001502217653001602232100003802248700002602286700002102312700002102333700002002354856006402374 2016 eng d00aUlcer Protective Activity of Jatropha gossypiifolia Linn. in Wistar Rats0 aUlcer Protective Activity of Jatropha gossypiifolia Linn in Wist cMarch 2016 a61-660 v83 a

Background: Several synthetic drugs are useful in the treatment of peptic ulcer, but almost of these drugs are used in prolonging time, it may cause several adverse reactions. However, the herbal medicines are more potent to the treatment and minimize the side effects. Objective: To evaluate the methanol extract of Jatropha gossypiifolia Linn. (MEJG) for gastro protective activity against Wistar rats. Materials and Methods: Anti‑ulcer potency of MEJG (100 and 200 mg/kg, b.w.) was assessed using aspirin (200 mg/kg, p.o.) plus pylorus ligation ulcer model and the parameters studied were ulcer index (UI), gastric juice volume, pH, total acidity, and total acid output. Same extract was studied by ethanol‑induced (80%, 5 mL/kg, intragastrically) ulcer model, and the UI and biochemical parameters were studied. Results: The oral administration of MEJG (100 and 200 mg/kg) significantly (P < 0.001) attenuated the ulcer score and anti‑secretary parameters (such as the volume of gastric content, free acidity, total acidity, and total acid output) in the aspirin plus pylorus ligation rats. The extract also significantly attenuated (P < 0.001) ulcer score in ethanol‑induced ulcer model and lipid peroxidation level and significantly increased the level of glutathione peroxides, catalase, and superoxide dismutase activity. The MEJG may possess active constituents such as alkaloids, glycosides, flavonoids, and terpenes, which may play a major role in gastroprotective effect in Wistar rats. Conclusion: The present study provides scientific support for the anti‑ulcer activities of extracts of JG and also claimed that antioxidant potential of the extracts. However, substantiates the traditional claims for the usage of this drug in the treatment of gastric ulcer.

10aAntioxidant enzymes10aanti‑ulcer10aAspirin10aethanol10ajatropha gossypiifolia10aranitidine10aWistar rats1 aVijayakumar, Arumugam, Ramamoorth1 aDaniel, Epison, Prabu1 aIlavarasan, Raju1 aVenkataraman, S.1 aVijayakumar, S. uhttps://phcogres.com/article/2016/8/5/1041030974-8490178640