02415nas a2200205 4500008004100000245010900041210006900150260001400219300001200233490000600245520175600251653002302007653003402030653001302064100002002077700001702097700001702114700001402131856006402145 2015 eng d00aAnti-inflammatory and Antiarthritic Activity of UNIM-301 (a polyherbal unani formulation) in Wistar Rats0 aAntiinflammatory and Antiarthritic Activity of UNIM301 a polyher cJune 2015 a188-1920 v73 a

Background: UNIM-301 is a polyherbal formulation used in the Unani system of medicine for the treatment of joint pain and rheumatoid arthritis (RA). Objective: The objective was to evaluate the anti-inflammatory and antiarthritic activity of UNIM-301 in carrageenan-induced paw edema and complete Freund's Adjuvant (CFA) induced arthritis. Materials and Methods: The anti-inflammatory and antiarthritic activity of UNIM-301 was evaluated using carrageenan-induced paw edema and CFA induced animal arthritis models, respectively, in doses of 250, 500, and 1000 mg/kg body weight. Anti-inflammatory activity of UNIM-301 was evaluated using carrageenan-induced paw edema model using a digital plethysmometer. Anti-arthritic activity was evaluated using CFA induced arthritis, and joint sizes were measured at regular intervals using a micrometer screw gauge. Serum was collected and subjected to estimation of pro-inflammatory cytokine. Indomethacin 3 mg/kg body weight) was used as a standard drug in both the models. The acute and chronic toxicity study was carried out to evaluate the safety of the test drug. Results: UNIM-301 treatment produced a dose-dependent reduction in paw edema and paw thickness in carrageenan-induced paw edema and CFA-induced arthritis, respectively, as compared to control. UNIM 301 also reduced the expression of pro-inflammatory mediator in a dose-dependent manner as compared to control. Conclusion: The result of the present study suggests that anti-inflammatory and anti-arthritic activity of UNIM-301, which might be accredited to inhibitory activity on pro-inflammatory cytokines to its various individual constituents.

10aAdjuvant Arthritis10aCarrageenan-induced Paw Edema10aUNIM-3011 aSingh, Surender1 aKumar, Rohit1 aJain, Hitesh1 aGupta, YK uhttps://phcogres.com/article/2015/7/2/1041030974-8490150515