01832nas a2200205 4500008004100000245012300041210006900164260001400233300001200247490000600259520114000265653003501405653001701440653002301457653001401480100002001494700003001514700002501544856005701569 2017 eng d00aEx vivo Antispasmodic Activity of Aqueous Extract of Flowers of Muntingia calabura Linn. on Excised Rabbit’s Jejunum0 aEx vivo Antispasmodic Activity of Aqueous Extract of Flowers of  cJuly 2017 a301-3030 v93 a

Objective: The present study has been undertaken with the main objective of evaluating the aqueous extract of flowers of Muntingia calabura for antispasmodic activity on isolated rabbit’s jejunum. Materials and Methods: The study was carried out on isolated rabbit’s jejunum preparations. The aqueous extract of flowers of M. calabura was applied in different doses by cumulative manner without washing the tissue. Spontaneous contractions abolished by the extract were recorded. Results: In isolated rabbit’s jejunum preparation, the flower extract of M. calabura inhibited the spontaneous contractions in a concentration‑dependent manner with IC100 value of 36 ± 3.02 μg/mL, which is potent than the standard drug verapamil with IC100 value of 40 ± 1.02 μg/mL on the rabbit’s jejunum. Conclusion: The aqueous extract of flowers of M. calabura exhibits significant dose‑dependent relaxations of spontaneous contractions in isolated rabbit’s jejunum preparations.

10aEx vivo antispasmodic activity10aIC100 values10aMuntingia calabura10aVerapamil1 aVadivel, Kannan1 aKumar, Gollapudi, Sandeep1 aBabu, Sitty, Manohar uhttps://phcogres.com/article/2017/9/3/104103prpr9916