02559nas a2200241 4500008004100000245014400041210007100185260001500256300001200271490000600283520174900289653001302038653002002051653002702071653001802098653002102116653001902137100002802156700001902184700002102203700002902224856006402253 2017 eng d00aHepatoprotective, Antihyperlipidemic, and Anti‑inflammatory Activity of Moringa oleifera in Diabetic‑induced Damage in Male Wistar Rats0 aHepatoprotective Antihyperlipidemic and Anti‑inflammatory Activi cApril 2017 a182-1870 v93 a

Background: The number of individuals with diabetes is increasing daily, and diabetes is presently estimated to affect about 422 million adults worldwide. Conventional drugs used to treat diabetes are not without severe side effects, accessibility, and affordability. This study elucidates the potential effects of Moringa oleifera (MO) leaves extract to manage and treat diabetes induced in male Wistar rats. Materials and Methods: Adult male Wistar rats were randomly divided into four groups (n = 12/group): NC – nondiabetic rats (positive control), MO – nondiabetic-treated rats, DM – diabetic rats (negative control), DM + MO – diabetic-treated rats. Hepatic enzymes and biochemical parameters as well as antioxidant capacity and inflammatory cytokine levels were assessed. Levels of low-density lipoprotein, high-density lipoprotein, and total cholesterol were evaluated. Results: Oral administration of methanolic extract of MO (250 mg/kg) to diabetic rats for 42 days showed a significant reduction in hepatic enzyme markers and normalized lipid profile parameters in the serum compared to normal control group. Treatment also increased the level of antioxidant capacity and alleviated inflammatory biomarkers of the liver. Histology sections of the liver tissue showed protective effect of MO in treated rats. Conclusions: MO showed hepatoprotective, anti-inflammatory, and lipid-lowering effects against streptozotocin-induced hepatotoxicity. Histological section demonstrated specific alterations in the liver of the diabetic and nondiabetic male Wistar rats while MO treatment revealed improvement in liver alterations.

10aDiabetes10aHepatic enzymes10aInflammatory cytokines10aLipid profile10aMoringa oleifera10aStreptozotocin1 aOmodanisi, Elizabeth, I1 aAboua, Yapo, G1 aChegou, Novel, N1 aOguntibeju, Oluwafemi, O uhttps://phcogres.com/article/2017/9/2/1041030974-8490204651