01901nas a2200193 4500008004100000245011500041210006900156260001400225300001200239490000700251520125300258653001601511653001901527653002501546653002801571100002201599700002701621856005901648 2018 eng d00aEvaluation of AntiCancer Activity of Methanolic Extract of Hiptage benghalensis (L.) Kurz on Cancer Cell Lines0 aEvaluation of AntiCancer Activity of Methanolic Extract of Hipta cJuly 2018 a309-3130 v103 a

Aim and Background: This study aimed to study the anticancer effects of Hiptage benghalensis (L.) kurz using various human cancer cell cultures, in vitro using 3‑(4,5‑Dimethylthiazol‑2‑yl)‑2,5‑diphenyltetrazolium bromide MTT assay. Materials and Methods: Human cervical carcinoma (HeLa) cells, human breast cancer (MCF‑7) cells, and human neuroblastoma (IMR‑32) cells were maintained in a 5% CO2 incubator at 37°C. Different concentrations of an extract of H. benghalensis in serum‑free culture medium were freshly prepared and used for cytotoxic activity using MTT assay activity. Results: Among the plant extract had revealed that, the greater percentage inhibition in all types of cancer cells in a dose‑dependent manner using MTT assay. The concentration of the extract causing 50% cell death values of methanolic extract of H. benghalensis were found to be 50.73, 47.90, and 53.76 μg/mL against HeLa, MCF‑7, and IMR‑32, respectively. Conclusion: H. benghalensis methanolic extract were showed increased percentage inhibition of MCF 7, HeLa, and IMR 32 cells using MTT assay.

10acaspase‑310aCell viability10aHiptage benghalensis10aReactive oxygen species1 aBhukya, Babu, Rao1 aYellu, Narsimha, Reddy uhttps://phcogres.com/article/2018/10/3/104103prpr10217