02276nas a2200217 4500008004100000245007200041210006900113260001800182300001000200490000600210520162100216653001501837653001401852653002001866653001501886100002401901700002701925700002001952700002201972856006401994 2017 eng d00aNew Cytotoxic Cembranoid from Indonesian Soft Coral Sarcophyton sp.0 aNew Cytotoxic Cembranoid from Indonesian Soft Coral Sarcophyton  cFebruary 2017 a65-680 v93 a

Context: Sarcophyton is a soft coral species that contains various secondary metabolites with cytotoxic activity. The production of cytotoxic compounds in soft corals is suggested as their allelochemical to win space competition. Therefore, if a particular soft coral species dominates a reef area, it may suggest to contain interesting bioactive compounds. Aims: This research aimed to characterize the cytotoxic compounds in dominant soft coral species (Sarcophyton sp.) on the reef at the Western side of Mahengetang Island, Indonesia. Subjects and Methods: Isolation of cytotoxic compounds through ethanol extracts had been done with preparative high‑performance liquid chromatography and bioassay‑guided fractionation by MCF‑7 (breast) cancer cell lines. The structures of each cytotoxic compounds were elucidated on the basis of mass and nuclear magnetic resonance spectroscopic studies. Results: Elucidation through all compounds found a new cembranoid, namely, 2‑hydroxy‑crassocolide E (1), alongside with 5 known cembranoids; sarcophytoxide (2), sarcrassin E (3), 3,7,11‑cembreriene‑2,15‑diol (4), 11,12‑epoxy‑Sarcophytol A (5), and sarcophytol A (6). All of these cembranoids were showed to inhibit the growth of MCF‑7 (breast) cancer, with 50% inhibition of tumor cell lines growth lower than 30 mg/L. Conclusions: Results of this study suggest that a soft coral species which dominate a reef area is a potential source for various bioactive compounds.

10aCembranoid10aCytotoxic10aSarcophyton sp.10aSoft coral1 aJanuar, Hedi, Indra1 aZamani, Neviaty, Putri1 aSoedharma, Dedi1 aChasanah, Ekowati uhttps://phcogres.com/article/2017/9/1/1041030974-8490199779