02600nas a2200229 4500008004100000245013900041210006900180260001800249300001000267490000700277520185200284653001802136653001302154653001402167653001502181653001802196653001702214100003502231700002302266700002302289856005802312 2018 eng d00aThermogenic Blend Alone or in Combination with Whey Protein Supplement Stimulates Fat Metabolism and Improves Body Composition in Mice0 aThermogenic Blend Alone or in Combination with Whey Protein Supp cFebruary 2018 a37-430 v103 a

Background: Certain food ingredients promote thermogenesis and fat loss. Similarly, whey protein improves body composition. Due to this potential synergistic effect, a blend of thermogenic food ingredients containing African mango, citrus fruit extract, Coleus forskohlii, dihydrocapsiate, and red pepper was tested alone and in combination with a whey protein supplement for its effects on body composition in sedentary mice during high‑fat diet. Objective: The objective of this study was to evaluate the interaction of thermogenic foods on improving body composition during consumption of an unhealthy diet. Materials and Methods: C57BL/6J young adult male mice (n = 12) were placed on a 60% high‑fat diet for 4 weeks and subsequently randomly assigned to receive daily dosing by oral gavage of vehicle, the novel blend alone or with whey protein supplement for another 4 weeks. Body composition, thermal imaging of brown adipose tissue (BAT), mitochondrial BAT uncoupling protein 1 (UCP1), and plasma levels of leptin were assessed. Results: Novel blend alone and in combination with protein supplement attenuated body weight gain, fat, and increased surface BAT temperature in comparison to vehicle control and to baseline (P < 0.5). The combination of novel blend and whey protein supplement also significantly increased UCP1 protein expression in BAT mitochondria in comparison to vehicle control and novel blend alone (P < 0.5). Conclusions: These data indicate that this novel blend stimulates thermogenesis and attenuates the gain in body weight and fat in response to high‑fat diet in mice and these effects were improved when administered in combination with whey protein supplement.

10aAfrican mango10aCapsiate10aForskolin10aSynephrine10aThermogenesis10aWhey protein1 aVieira‑Brock, Paula, de Lima1 aVaughan, Brent, M.1 aVollmer, David, L. uhttps://phcogres.com/article/2018/10/1/104103prpr5317