02164nas a2200241   4500008004100000245009600041210006900137260001400206300001200220490000700232520139900239653002401638653001501662653002001677653001401697653001001711100003101721700003201752700002801784700002201812700002601834856006201860       2025                        eng d00aPhytoflavonoids-A Future Perspective for the Therapeutic Potential of Alzheimer’s Disease0 aPhytoflavonoidsA Future Perspective for the Therapeutic Potentia  cJune 2025  a788-7950 v173 a<p class="rtejustify">Millions of people suffer from the neurodegenerative diseases like Alzheimer's Disease (AD) worldwide. Due to their complex pathology, no effective pharmacological treatment has been found to date, despite extensive research. Developing new, effective therapeutic agents to cure these disease remains a major challenge. Although the cause of AD remains apparent, numerous studies indicates that oxidative stress and neuro-inflammation lead to neurodegeneration in the central nervous system and play vital role in AD morbidity and progression. Flavonoids, which are found widely in nature, exhibit anti-oxidative, anti-inflammatory, anti-mutative, anti-microbial, and neuroprotective properties, so have potential to treat these two kinds of disease. In this review, we focus on the anti-oxidative and neuroprotective action of flavonoids in attenuating Alzheimer’s disease, and how they might be harnessed in the development of new pharmacological agents to treat these diseases. Some Flavonoids compounds Quercetin, Rutin, hesperidin, Naringinin, Epigallocatechin-3-gallate, displayed to be effective in AD. Considerable studies have demonstrated the anti-AD effects of flavonoids through various in vitro and in vivo models. However, more rigorous studies are needed to be done for flavonoids to develop into effective drugs and apply them to clinical practice.</p>
10aAlzheimer's disease10aFlavonoids10aNeuroprotective10aQuercetin10aRutin1 aKamalakannan, Karthigadevi1 aSeetharaman, Shanmuganathan1 aSockalingam, Anbazhagan1 aVijayaRani, Reeta1 aSubramanian, Kavimani  uhttps://phcogres.com/article/2025/17/3/105530pres20252213