02427nas a2200241 4500008004100000245011500041210006900156260001500225300001200240490000700252520159400259653003101853653001301884653002501897653002601922100002901948700002601977700003302003700003302036700002902069700002502098856006202123 2025 eng d00aEvaluation of in vitro Anti-Inflammatory Activity of Trichosanthes palmata against the Denaturation of Protein0 aEvaluation of in vitro AntiInflammatory Activity of Trichosanthe cApril 2025 a654-6580 v173 a

Background: Trichosanthes palmata Lour. (Cucurbitaceae) is one of the important medicinal plants used traditionally for the treatment of asthma, earache, ophthalmia, leprosy, fever as well as used in the treatment of migraine. To validate folk used of Trichosanthes palmata as anti-inflammatory remedy. The leaves of Trichosanthes palmata were used for successive extraction (Maceration) with increasing polarity solvents. Ethanolic extract was selected for anti-inflammatory activity. In vitro anti-inflammatory activity was evaluated using protein denaturation method at different concentrations. Diclofenac sodium was used as standard drug. Objectives: To evaluate the in vitro anti-inflammatory effect of ethanolic extract of leaves of Trichosanthes palmata against the denaturation of protein. Materials and Methods: Inhibition of protein denaturation method was evaluated for anti-inflammatory activity. Results: The ethanolic extract of Trichosanthes palmata exhibited anti-inflammatory activity by protein denaturation method. Conclusion: The ethanolic extract from Trichosanthes palmata leaves exhibited significantly enhanced anti-inflammatory activity with increasing concentrations. This effect is likely attributed to the presence of active phytocompounds, including flavonoids, triterpenoids and related polyphenols. Consequently, Trichosanthes palmata holds potential as an anti-inflammatory agent.

10aanti-inflammatory activity10ain vitro10aProtein Denaturation10aTrichosanthes palmata1 aPatel, Arshu, Pirmhommad1 aDhavan, Sayee, Promod1 aShinde, Tejasvee, Ramchandra1 aSonawane, Manisha, Dhondiram1 aPatel, Hetali, Amrutbhai1 aWani, Nilima, Mahesh uhttps://phcogres.com/article/2025/17/2/105530pres20252089