02549nas a2200313   4500008004100000245007700041210006900118260001500187300001200202490000700214520165700221653000901878653002801887653001301915653002101928653002001949653002201969653002401991653002102015653001202036653001902048100002102067700001902088700001702107700001602124700001802140700001502158856006202173       2025                        eng d00aExploring the Role of Phytoconstituents for Endocrine Disorder: A Review0 aExploring the Role of Phytoconstituents for Endocrine Disorder A  cApril 2025  a402-4100 v173 a<p class="rtejustify">The endocrine system consists of various glands responsible for secreting hormones that regulate metabolism, growth, reproduction, and other physiological processes. Disruptions in this system, termed endocrine disorders, are linked to numerous health issues, such as obesity, diabetes, cardiovascular diseases, and metabolic syndromes. Moreover, the significance of factors such as life stage, gender and dietary habits in influencing health risks associated with endocrine disruption cannot be overstated. Synthetic medications for these conditions often have adverse side effects like hypoglycemia and heart complications, highlighting the need for alternative treatments. Herbal and natural remedies have shown promise in managing these disorders due to their lower toxicity and minimal side effects. Phytochemicals and poly-herbal therapies are emerging as effective strategies for addressing endocrine and metabolic disorders, influencing molecular targets like AMP-Activated Protein Kinase (AMPK) and Nuclear factor erythroid-2- related factor (Nrf2). Specific disorders such as diabetes, Addison’s disease, and hyperthyroidism are characterized by hormone imbalances, with molecular mechanisms involving insulin resistance, cortisol dysregulation, and thyroid dysfunction. Additionally, the role of factors such as life stage, gender, and dietary habits in modulating endocrine disruption-associated health risks is crucial. Natural products, including flavonoids, catechins, resveratrol, and terpenes, are being explored for their therapeutic potential in regulating hormone levels and improving metabolic health.</p>
10aAMPK10aCardiovascular diseases10aDiabetes10aEndocrine system10aHerbal medicine10aHormone imbalance10aMetabolic disorders10aNatural Products10aObesity10aPhytochemicals1 aBhandari, Shweta1 aTrivedi, Rahul1 aGarg, Vishal1 aSaini, Ajay1 aGupta, Manish1 aSingh, Ram  uhttps://phcogres.com/article/2025/17/2/105530pres20252070