02469nas a2200229 4500008004100000245010800041210006900149260001700218300001200235490000700247520168000254653004001934653003701974653002202011653002002033653003302053653001802086100003602104700001902140700001802159856006202177 2025 eng d00aEffect of a Thermogenic Composition on Healthy Adult Women and Men in a 12-Week Weight Management Study0 aEffect of a Thermogenic Composition on Healthy Adult Women and M cJanuary 2025 a100-1070 v173 a

Background: Weight loss medications can have severe side effects and thus there is a need to identify safe and effective alternative treatments. Dietinduced thermogenesis and a potential stimulation of fat metabolism might be achieved by consumption of certain foods. Objectives: The aim of the present study was to explore the effects of a Thermogenic Composition (TC) composed of dihydrocapsiate, red pepper (Capsicum annuum), citrus (Citrus spp.) peel extract, Coleus forskohlii and African mango (Irvingia gabonensis) to support body composition, weight management and improve satiety in healthy adults. Methods: Thirty-six participants were instructed to take TC daily over a 12-week interval. Body composition, energy levels, feelings of hunger and satiety were measured. Results: Body Fat percentage showed significant reduction at week 7 and 12 compared to week 0. Waist to Hip Ratio results showed significant reduction at week 7 compared to week 0. Feelings of Hunger and Feelings of Fullness showed significant improvement at week 3, 7 and 12 compared to week 0. Desire to Eat showed a significant reduction at week 3,7 and 12 compared to week 0. Appetite showed significant reduction at week 7 and 12 compared to week 0. Conclusion: TC showed significant improvements in hunger cravings and feelings of fullness as well as significant reduction in percent body fat and waist to hip ratio. The good safety and tolerability profile of TC supported its use as a daily nutritional supplement for weight management and body composition.

10aAfrican mango (Irvingia gabonensis)10aCitrus (Citrus spp) peel extract10aColeus forskohlii10adihydrocapsiate10aRed pepper (Capsicum annuum)10aThermogenesis1 aJaramillo, Millerlandy, Popayan1 aVollmer, David1 aHan, Xuesheng uhttps://phcogres.com/article/2025/17/1/105530pres20251936