02312nas a2200241 4500008004100000245013100041210006900172260001700241300001200258490000700270520149200277653002401769653001801793653002301811653001701834653003101851100002401882700002801906700002901934700002501963700002001988856006202008 2025 eng d00aGreen Synthesis of Gold Nanoparticles Using Sphaeranthus amaranthoides: Drug Loading and Anticancer Properties in Nanomedicine0 aGreen Synthesis of Gold Nanoparticles Using Sphaeranthus amarant cJanuary 2025 a108-1140 v173 a

This study introduces a sustainable method for synthesizing anisotropic Sphaeranthus amaranthoides leaf extract reduced gold nanoparticles (S-GNPs) by utilizing the phenolic compounds present in Sphaeranthus amaranthoides leaf extract. Background: Unlike conventional chemical methods, this eco-friendly approach leverages natural sunlight as a catalyst and hyaluronic acid for stabilization, providing a green, scalable solution. Objectives: The research aims to develop a biocompatible, stable nanoparticle system for targeted cancer drug delivery. Materials and Methods: The nanoparticles were synthesized and characterized using Surface Plasmon Resonance (SPR) and High-Resolution Transmission Electron Microscopy (HRTEM) to confirm size, morphology, and zeta potential. Stability was tested in saline solutions at physiological pH. In vivo toxicity studies were conducted using zebra fish larvae, demonstrating high biocompatibility at concentrations below 100 μg/mL. Conclusion: Dexamethasone-loaded S-GNPs exhibited significant cytotoxicity against THP-1 Acute Monocytic Leukemia cells, underscoring the potential of this eco-friendly synthesis method for cancer therapy applications. These findings highlight the viability of S-GNPs as effective, biocompatible vehicles for targeted drug delivery, presenting a sustainable alternative to conventional nanoparticle systems.

10aAnticancer activity10aDexamethasone10aGold nanoparticles10aLeaf extract10aSphaeranthus amaranthoides1 aKhan, Iram, Shabbir1 aYanamadala, Swarnalatha1 aChinnaiyan, Senthilkumar1 aChiterasu, Narendran1 aKannan, Sidhika uhttps://phcogres.com/article/2025/17/1/105530pres20251946