02594nas a2200277 4500008004100000245021500041210006900256260001700325300001200342490000700354520161900361653003001980653001502010653002402025653002302049653003402072100001602106700002102122700001802143700001702161700001902178700001902197700001402216700002702230856005902257 2024 eng d00aHistological Analysis Reveals that Red Grape Seed Extract (Vitis vinifera L.) Rejuvenates Antioxidant Enzymes in Male Albino Rats (Wistar strain) with D-Galactose-Induced Alzheimer's Disease (AD) Brain Regions0 aHistological Analysis Reveals that Red Grape Seed Extract Vitis  cOctober 2024 a828-8360 v163 a

Aim: Oxidative stress is a significant risk factor for Alzheimer’s Disease (AD) as it promotes lipid peroxidation and diminishes antioxidants in the nervous system. This study investigates the effect of Red Grape Seed Extract (RGSE), a bioflavonoid with medicinal properties, on antioxidant levels and lipid peroxidation in specific central nervous system regions of albino rats. Materials and Methods: Male Wistar strain albino rats were divided into three groups: Group-I (control), Group-II (treated with D-galactose at 120 mg/kg body weight for 30 days), and Group-III (treated with D-galactose and RGSE at 120 mg/kg body weight concurrently for 30 days). The cerebral cortex, cerebellum, hippocampus, and pons medulla regions were analyzed. Lipid peroxidation and antioxidant enzyme activities (catalase, glutathione reductase, superoxide dismutase) as well as non-enzymic antioxidants (reduced glutathione, vitamin C, vitamin E) were measured. Results: In the brain regions of AD rats, lipid peroxidation levels increased, and the activities of antioxidant enzymes and levels of non-enzymic antioxidants significantly decreased compared to the control group. However, in the AD rats treated with RGSE, antioxidant defenses were restored, and lipid peroxidation levels normalized. Conclusion: Red Grape Seed Extract improves the antioxidant status and reduces free radical-induced lipid peroxidation in the central nervous systems of Alzheimer’s rat models, suggesting its potential therapeutic benefit in AD.

10aAlbino Rats Free radicals10aAlzheimers10aAntioxidant enzymes10aLipid peroxidation10aRed Grape Seed Extract (RGSE)1 aKiran, Uday1 aReddy, Ramasubba1 aKumar, Ramesh1 aNaik, Muniya1 aRao, Narasimha1 aJayasankar, A.1 aAruna, C.1 aKumar, Veera, Nagendra uhttps://phcogres.com/article/2024/16/4/105530pres16495