02391nas a2200181 4500008004100000245012300041210006900164260001500233300001200248490000700260520180600267653001602073653001802089653001802107653000902125100001602134856005902150 2024 eng d00aEvaluation of Mixer of Essential Oils and their Standard Components against Fungi Causing Superficial Mycosis in Human0 aEvaluation of Mixer of Essential Oils and their Standard Compone cApril 2024 a339-3460 v163 a

Background: Dermatophytoses are responsible for almost one-quarter of all fungal infections globally. When treatable, these challenging fungal infections of the skin, hair, and nails are becoming more resistant to standard antifungal medications and frequently call for lengthy therapeutic regimens. Objectives: Essential oils have been used to cure a range of diseases for ages. In present study combination effect of volatile oils obtained from Trachyspermum ammi, Coriandrum sativum and Cymbopogon martinii were evaluated against four selected dermatophytic fungi namely Microsporum canis, M. fulvum, Trichophyton rubrum and T. mentarophytes. Materials and Methods: Four combinations like T. ammi + Cymbopogon martinii, T. ammi + Coriandrum sativum, Cymbopogon martinii + C. sativum, T. ammi + Cymbopogon martinii + C. sativum were prepared and evaluated through semisolid agar antifungal susceptibility methods. Results: During present investigation T. rubrum was found to be most resistant fungus. Combination of T. ammi with C. sativum showed excellent results as compared to T. ammi and C. martinii. Combination of C. martinii and C. sativum was less effective as compared to other combinations. MIC was ranging from 0.1 μL/mL to 0.4 μL/mL against test fungi. Conclusion: Although essential oils are frequently combined in the use of aromatherapy to cure infectious disorders, there is very little data to back up this practice. This study supports the concurrent usage of blended essential oils in some way.

10aCombination10aDermatophytes10aEssential oil10aMIC.1 aJain, Neetu uhttps://phcogres.com/article/2024/16/2/105530pres16243