02274nas a2200265 4500008004100000245007500041210006900116260001500185300001200200490000700212520146200219653001601681653000801697653001801705653001901723653002801742653002401770100002801794700002201822700003001844700002701874700002801901700002001929856005901949 2024 eng d00aHyperlipidemic Potential of Polyherbal Siddha Formulation D5 Chooranam0 aHyperlipidemic Potential of Polyherbal Siddha Formulation D5 Cho cApril 2024 a376-3830 v163 a

Background: Hyperlipidemia is an important public health problem with increasing incidence and prevalence worldwide. D5 Chooranam is a synergetic Siddha polyherbal formulation designed by Central Council for Research in Siddha which is under patent process. Materials and Methods: In this study assessment of antihyperlipidemic activity of D5 Chooranam was carried out using high fat diet-induced hyperlipidemic model. After 8 weeks of induction hyperlipidemia, the male Wistar rats were treated orally with 250 mg/kg, 500 mg/kg and 750 mg/kg of D5 Chooranam for 6 weeks. Results: The results demonstrated significant hypolipidemic activity by lowering total cholesterol, Low Density Lipoprotein (LDL), Very Low-Density Lipoprotein (VLDL), and triglycerides and by increasing HDL levels compared to hyperlipidemic rats. Atorvastatin (10 mg/kg) was used as a positive control. The reduced AST and ALT levels showed its protective role against hepatic damage. Histopathological findings in rat liver supported the protective role of D5 Chooranam in HFD-induced fatty liver. No significant changes in the renal and cardiac markers provide evidence that D5 Chooranam may not possess serious side effects. Conclusion: Therefore, the study suggests that D5 Chooranam could be effective in treating hyperlipidemia.

10acholesterol10aHDL10aHigh fat diet10aHyperlipidemia10aLow density lipoprotein10aSiddha formulation.1 aReddy, Gaddam, Dayanand1 aGanesan, Rethinam1 aJayavaram, Manikantavinay1 aG, Venkata, Narasimhak1 aKrishnamoorthy, Bhavani1 aAhamed, Shahana uhttps://phcogres.com/article/2024/16/2/105530pres16247