02494nas a2200217 4500008004100000024000700041245010800048210006900156260001800225300001200243490000700255520177000262653001902032653002202051653003802073100004402111700002502155700002102180700001602201856005902217 2023 eng d a1300aAnti-arthritic and Anti-inflammatory Activity of Ayurvedic Polyherbal Formulation in Laboratory Animals0 aAntiarthritic and Antiinflammatory Activity of Ayurvedic Polyher cDecember 2023 a110-1170 v163 a

Background: RD/M.ph.AA-01 is an Ayurvedic polyherbal formulation, developed for amavata, which is associated with chronic inflammatory autoimmune diseases. Objectives: The study was planned to evaluate the anti-arthritic and anti-inflammatory activity of RD/M.ph.AA-01 in laboratory animals. Materials and Methods: Anti-arthritic activity of RD/M.ph.AA-01 was evaluated at 270 and 405 mg/kg doses against Complete Freund’s Adjuvant (CFA)-induced arthritis. Anti-inflammatory activity was studied using cotton pellet granuloma and formalin-induced edema in rat models. The effect of topical application of RD/M.ph.AA-01 on Croton oil ear edema in mice was also investigated. Results: Arthritis induction caused a significant (p<0.05) alteration in paw size, hematology, serum parameters, edematous tissue parameters, lipid peroxidation in the liver and histopathology of joints. These alterations were significantly (p<0.05) prevented by treatment with RD/M.ph.AA-01. In the cotton pellet granuloma, RD/M. ph.AA-01 supplementation caused significant (p<0.05) improvement in the weight of granuloma tissue, serum parameters, lipid peroxidation in the liver and histopathological changes in granuloma tissue. A significant (p<0.05) improvement in paw size, serum parameters and liver lipid peroxidation were observed by RD/M.ph.AA-01 treatment in the formalin-induced edema model. The RD/M.ph.AA-01 also significantly (p<0.05) suppressed Croton oil-induced ear edema. Conclusion: These findings showed that RD/M.ph.AA-01 possesses potent anti-arthritic and anti-inflammatory activity.

10aAnti-arthritic10aAnti-inflammatory10aAyurvedic polyherbal formulation.1 aBasavarajaiah, Chandrasekar, Sandanapal1 aPawar, Anil, Tukaram1 aRamappa, Harisha1 aSetty, Vani uhttps://phcogres.com/article/2023/16/1/105530pres16113