02260nas a2200253 4500008004100000024000700041245006500048210006300113260001800176300001000194490000700204520154100211653002601752653001501778653002401793653002301817653001701840100001601857700001701873700002001890700002201910700001601932856005801948 2023 eng d a0300aCalotropin: Natural Phytomolecules for Cutting-edge Features0 aCalotropin Natural Phytomolecules for Cuttingedge Features cDecember 2023 a19-250 v163 a

Phytochemical is a collective term for plant chemicals with varied structure and function. The most common sources of phytochemicals are fruits, vegetables, whole grains, nuts and seeds, and other plant foods. Calotropin is a pharmacologically active compound isolated from milkweed plants like Calotropis procera, Calotropis gigantea, and Asclepias curassavica that belong to the Asclepiadaceae family which is used for medicinal purposes in many Asian countries. Calotropin is identified as a highly potent cardenolide that has a similar chemical structure to cardiac glycosides (such as digoxin and digitoxin). Among cardenolides, calotropin is identified as the most promising agent. Calotropin has cytotoxic and anti-tumor impacts, with cancers of the breast, colon, lung, and leukemia malignancies exhibiting the most significant effects. The effects of calotropin on cancer have been extensively studied in preclinical pharmacological studies in vitro using cancer cell lines and in vivo in experimental animal models that have targeted antitumor mechanisms and anticancer signaling pathways. During ancient times, calotropin was utilized in various techniques. A macerated bark extract is frequently utilized for de-hearing hides and tanning. Calotropin is a particularly effective abortifacient or interceptive agent in females. Cardenolide calotropin is poisonous. This critique focused on its chemistry and therapeutic activity in various cancer cells.

10aAsclepias curassavica10aCalotropin10aCalotropis gigantea10aCalotropis procera10aCardenolide.1 aNag, Sourav1 aPaul, Reshmi1 aMondal, Sumanta1 aPanigrahi, Naresh1 aRoy, Partha uhttps://phcogres.com/article/2023/16/1/105530pres1613