02910nas a2200265 4500008004100000024000700041245014800048210006900196260001400265300001200279490000700291520204600298653001602344653001802360653003002378653001602408653002302424100003202447700002002479700001902499700002802518700001702546700002102563856006002584 2023 eng d a1400aEvaluation of Protective Effects of Polyphenols of the Marine Brown Alga Ecklonia cava against Potassium Bromate Induced Nephrotoxicity in Rats0 aEvaluation of Protective Effects of Polyphenols of the Marine Br cJune 2023 a544-5500 v153 a

Background: Ecklonia cava is a kelp (brown algae) genus belonging to Lessoniaceae with plenty of Eckol-type phlorotannins. It exhibits antioxidant, anti-inflammatory, and antibacterial activity. Objectives: This study investigated Ecklonia cava (EC) polyphenols for their protective effects against KBrO3-induced nephrotoxicity in rats. Materials and Methods: The polyphenolic fraction was isolated from EC. Group, I was control (untreated), and group II was administered KBrO3 (135 mg/kg b.w) intragastric for four weeks. Group III was administered ECPP (200 mg/kg b.w) concurrently with KBrO3 (135 mg/kg b.w) orally, and Group VI was administered Rutin (100 mg/ kg b.w) along with KBrO3 (135 mg/kg b.w) orally. The protective effects of ECPP on KBrO3-induced nephrotoxicity in rats were assessed for the biochemical parameters of serum, various antioxidant enzymes, and histopathological changes in kidneys. Results: The level of serum of Blood Urea Nitrogen (BUN), uric acid, and creatinine was suggestively augmented (p<0.001) when treated by KBrO3. The activity of antioxidant enzymes, superoxide dismutase, catalase, glutathione peroxidase, and FRAP (ferric ion reducing antioxidant parameter) were diminished (p<0.001). At the same time, lipid peroxidation and nitric oxide were raised (p<0.001) with KBrO3 treatment in the kidneys. In addition, the protein carbonyl level was amplified (p<0.001) with KBrO3 administration. Histological studies presented renal damage in KBrO3-treated animals where tissue injury was abridged in ECPP pretreatment groups. Conclusion: These results suggest that ECPP functions as an antioxidant in vivo by scavenging reactive oxygen species, which helps preclude oxidative renal injury in rats treated with KBrO3.

10aAntioxidant10aEcklonia cava10aNephroproductive activity10aPolyphenols10aPotassium bromate.1 aRedhwan, Moqbel, Ali Moqbel1 aSamaddar, Suman1 aMG, Hariprasad1 aHard, Sumaia, Abdulbari1 aDeka, Gitima1 aGodfrey, Anyembe uhttps://phcogres.com/article/2023/15/3/105530pres153057