02840nas a2200265 4500008004100000024000700041245012700048210006900175260001800244300001200262490000700274520201700281653001602298653001802314653001402332653002402346653001902370100002602389700002102415700001902436700001902455700001902474700002102493856006002514 2023 eng d a1800aPhytochemical Analysis and in vitro Antioxidant Potential of Aqueous and Ethanol Extracts of Irvingia gabonensis Stem Bark0 aPhytochemical Analysis and in vitro Antioxidant Potential of Aqu cFebruary 2023 a363-3720 v153 a

Background: Irvingia gabonensis extracts are documented to possess antidiabetic, hypocholesterolemic, and antioxidant activities. The phytochemical components of medicinal plants are responsible for their therapeutic properties, particularly those with antioxidant properties. Objectives: The quantitative phytochemicals and in vitro antioxidant properties of the aqueous and ethanol extracts of I. gabonensis stem bark were assessed in this study. Materials and Methods: Standard techniques were used to measure the concentrations of phenols, flavonoids, tannins, alkaloids, steroids, and saponins in water and alcohol extracts of this plant. Total Antioxidant Power (TAP) and the extract's capacity to scavenge free radicals including superoxide, nitric oxide, 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2-azino-bis-(3-ethylbenzoth iazoline-6-sulfonic acid) (ABTS+), β-carotene, and hydrogen peroxide were also evaluated. The extracts' Ferric-Reducing Potential (FRAP) was also assessed. Results: The alcohol extract had significantly (P < 0.05) higher concentrations of all the phytochemicals measured as well as near significantly (P <0.066) higher TAP in comparison to the aqueous extracts. In general, the in vitro antioxidant capacity of the ethanol extract surpassed that of the water extract. The ethanol extract had IC50 values that were comparable to or less than the reference standards for its ability to neutralize nitric oxide, H2O2, superoxide, and DPPH radicals. Conclusion: The outcomes of the quantitative phytochemical analysis and in vitro antioxidant effects of aqueous and ethanol extracts of I. gabonensis stem bark clearly show their potential as an excellent reservoir of bioactive compounds and scavengers of deleterious oxidants; properties that could be explored therapeutically.

10aAntioxidant10aFree radicals10ain vitro.10aIrvingia gabonensis10aPhytochemicals1 aOtitolaiye, Catherine1 aOmonkhua, Akhere1 aOriakhi, Kelly1 aOkello, Edward1 aOnoagbe, Iyere1 aOkonofua, Friday uhttps://phcogres.com/article/2023/15/2/105530pres152039