02190nas a2200253 4500008004100000024000700041245019300048210006900241260001800310300001200328490000700340520130100347653001701648653001601665653001801681653001901699653001901718100003001737700003101767700002401798700002201822700003201844856006001876 2023 eng d a1100aEssential Oils of Rosmarinus officinalis and Eucalyptus globulus Cultivated in the Mountainous Region of the State of Rio de Janeiro (Brazil): Chemical Profile and Antileishmanial Activity0 aEssential Oils of Rosmarinus officinalis and Eucalyptus globulus cFebruary 2023 a297-3060 v153 a

The present study aimed to characterize the chemical profile of essential oils of Rosmarinus officinalis (EORo) and Eucalyptus globulus (EOEg) cultivated in the mountainous region of the state of Rio de Janeiro, Brazil, and to verify the leishmanicidal potential, as well as to determine the cytotoxicity in vitro in mammalian cells. EORo had α-Pinene (37.99%), Cineol (21.48%), D-Verbenone (5.78%) and Limonene (3.28%) as major constituents. The EOEg had as major components Cineol (75.52%), Limonene (8.82%) and o-Cymeno (7.81%). The EOEg had a lower IC50 value of 14.03 ± 2.08 μg/mL, while EORo had an IC50 value of 31.12 ± 4.6 μg/mL, both during the 24-hr exposure period. In the 48-hr period, the IC50 value was almost twice as high with rosemary oil, while in eucalyptus oil there was no significant difference when exposed in this period. The selectivity of EOs was demonstrated in murine cells, showing almost 30 times less toxic to the cell than to the parasite. It can be concluded that this is a pioneering study on the potential of these essential oils against the leishmania parasite. Furthermore, the low toxicity effect on the host cell encourages future studies and in vivo applications.

10acytotoxicity10aE. globulus10aEssential oil10aLeishmanicidal10aR. officinalis1 aZauli, Rogéria, Cristina1 aSantos, Tarcísio, Martins1 aWisniewski, Alberto1 aXander, Patrícia1 aPascoal, Aislan, Cristina R uhttps://phcogres.com/article/2023/15/2/105530pres152032