02606nas a2200277 4500008004100000245018300041210007300224260001600297300001200313490000700325520162100332653002601953653001701979653001601996653001902012653002402031100002302055700002502078700002702103700003102130700002902161700002702190700002602217700002602243856005902269 2019 eng d00aAn Open‑Label, Multi‑Center, Prospective, Interventional, Clinical Study to Evaluate the Efficacy and Safety of Ayuvigo Forte Capsules in Patients Suffering from Oligospermia0 aOpen‑Label Multi‑Center Prospective Interventional Clinical Stud cAugust 2019 a290-2940 v113 a

Background: Oligospermia refers to semen with a low concentration of sperms. Oligospermia is one of the common causative factors of male infertility. Objectives: The objective of this study was to assess the efficacy and safety of Ayuvigo forte capsule in patients suffering from oligospermia. Materials and Methods: This was an open‑label, prospective, interventional, multi‑center clinical study. A total of 30 patients were completed the study. All patients were advised to consume two Ayuvigo forte capsules twice daily orally after meals with a cup of milk for 90 days. Data describing quantitative measures are expressed as a mean ± standard deviation. Results: The mean total sperm count, mean progressive sperm motility, and total number of spermatozoa increased significantly (P < 0.05) by 90.54%, 33.65%, and 98.88% at the end of the study, respectively. Most patients had shown significant (P < 0.05) improvement in subjective parameters of low sperm count assessed as per Ayurveda. Furthermore, significant (P < 0.05) improvement was observed in mean serum free testosterone level. No statistically significant (P > 0.05) changes were observed in mean serum luteinizing hormone, follicle‑stimulating hormone, prolactin, safety laboratory parameters, and vitals. Excellent overall efficacy and tolerability were observed in majority of patients. Conclusion: Ayuvigo forte capsule is safe and effective for the management of oligospermia.

10aAyuvigo forte capsule10aOligospermia10aSperm count10aSperm motility10aTestosterone level.1 aTamoli, Sanjay, M.1 aMundhe, Narendra, B.1 aDeshmukh, Devdatta, A.1 aPande, Shishir, Purushotta1 aKamde, Rahul, Ramkrushna1 aKumbhar, Vidyadhar, S.1 aUpasani, Sachin, Anil1 aMahadik, Swapnali, B. uhttps://phcogres.com/article/2019/11/3/104103prpr15818