02663nas a2200241 4500008004100000024000700041245008400048210006900132260001700201300001200218490000700230520191000237653001502147653002502162653002702187653002002214100002502234700002302259700002502282700002602307700002902333856005902362 2022 eng d a0600aDevelopment of a Gastroretentive Polyherbal Formulation and its Standardization0 aDevelopment of a Gastroretentive Polyherbal Formulation and its  cOctober 2022 a379-3900 v143 a

Background: Phytopharmaceuticals within the shape of the entire herb, plant parts, or separated bioactive constituents have been utilized broadly in therapeutics since antiquated times till date. The appealing use of drugs of the natural root has driven the requirement for standardization as per the WHO guidelines. Objectives: The main aim of the existing study was to formulate polyherbal gastroretentive capsules by using Carbopol 934 and 971P in different concentration ranges to get desired buoyancy rate. Materials and Methods: The prepared formulation was characterized by physico-chemical parameters and pharmaceutical quality control tests. Standard procedures were used to estimate the organoleptic properties, extractive values, and ash values of the crude drugs used in formulations. Extraction was carried out using Soxhlation followed by preliminary phytochemical evaluation and HPTLC fingerprinting of the extracts. The extracts were formulated into a gastroretentive polyherbal capsule and assessed for physical parameters. Results: The phytochemical assessment established the presence of flavonoids, alkaloids, saponins, steroids, and glycosides. Rf values obtained from the HPTLC studies of the extracts signified the presence of important phytoconstituents such as Shogaols, 6-Gingerol, 8-Gingerol, Glycyrrhizin, Andrographolides, Marmelosin, and Conessine. Percent Carr’s consolidation index ranging from 8.111 ± 0.157 to 8.827 ± 0.186, Hausner’s ratio between 1.088 ± 0.002 to 1.097 ± 0.002, and angle of repose below 30 are indicative of excellent flow property of the granules. Conclusion: The gastroretentive capsules PHF4 containing granules formulated using 75 mg Carbopol 971P showed a buoyancy effect of more than 24 hr with desired structural integrity.

10aExtraction10aHPTLC fingerprinting10aPolyherbal formulation10aStandardization1 aGupta, Manish, Kumar1 aKhade, Medha, Amol1 aSrivastava, Birendra1 aHyam, Supriya, Rajesh1 aGurav, Prashant, Basappa uhttps://phcogres.com/article/2022/14/4/105530pres14456