02078nas a2200265 4500008004100000245009500041210006900136260001400205300001200219490000700231520129900238653002201537653001001559653002601569653000901595653001101604100001401615700002701629700001901656700001801675700002101693700001801714700002101732856005901753 2022 eng d00aAnti-inflammatory Potential of Euphorbia helioscopia Extracts against RAW264.7 Macrophages0 aAntiinflammatory Potential of Euphorbia helioscopia Extracts aga cJuly 2022 a338-3410 v143 a

Background: Euphorbia helioscopia, commonly known as sun spurge, is one of the largest species of an annual herb in the family Euphorbiaceae, which is extensively distributed worldwide. In folk medicine, it is used to treat various ailments such as malaria, osteomyelitis, and gastrointestinal ailments. The anti-inflammatory potential of Euphorbia helioscopia extracts on LPS-stimulated RAW264.7 macrophages was investigated in this work. Results: The ethanol extract was found to markedly inhibit the pro-inflammatory cytokines (IL-6 and TNFα) production compared to the aqueous extract treated cells. Moreover, extracts downregulated the nitric oxide levels. Finally, in this study, we have shown that Euphorbia helioscopia exerts a potent pharmacological effect on reducing the inflammatory response in macrophages. Conclusion: The results of the experiment revealed that the Euphorbia helioscopia extracts used in this study have anti-inflammatory characteristics, with the ethanolic extract having the most. The ethanolic extract had the strongest anti-inflammatory impact in terms of greatest reduction of proinflammatory indicators including IL-6, TNF-, and NO.

10aAnti-inflammatory10aELISA10aEuphorbia helioscopia10aIL-610aTNF-α1 aJan, Iram1 aAndrabi, Nusrit, Iqbal1 aArfath, Yassir1 aAkram, Tazeem1 aKotra, Tusharika1 aAhmed, Zabeer1 aKumar, Mithilesh uhttps://phcogres.com/article/2022/14/3/105530pres14350