02585nas a2200217 4500008004100000245010000041210006900141260001400210300001200224490000700236520188400243653002402127653002402151653001802175653002602193653001902219653002502238100002702263700001802290856005902308 2022 eng d00aDetermination of Analgesic Potential of Ethanolic Extract of Brassica campestris Leaves in Rats0 aDetermination of Analgesic Potential of Ethanolic Extract of Bra cJuly 2022 a297-3030 v143 a

Background: Brassica campestris plant, a prominent member of Brassicaceae family, has documented therapeutic potential in the common cold, as an antibacterial, antiprotozoal, and to some extent an analgesic in folk medicine. Objectives: The present study aimed to determine the antinociceptive activity and analgesic potential of the ethanolic extract of the leaves of the Brassica campestris plant in rats. Materials and Methods: The antinociceptive potential and analgesic effects of the Brassica campestris leaves extract were evaluated by using the hot plate test and formalin analgesia method. The data were presented as mean ± standard error of the mean (M ± SEM). One-way analysis of variance [ANOVA] followed by Tukey’s multiple comparison tests were performed for statistical analysis. P-value was considered signicant at < 0.05. Results: The withdrawal latency period was noticed to be gradually and signicantly prolonged after 400mg/kg oral administration of Brassica campestris leaves extract reaching a maximum of 12.73 ± 0.61 sec (p<0.05) as compared to control rats (6.13 ± 0.09 sec) in hot plate test. The antinociceptive behavior of experimental rats was also found quite signicant in both phases of formalin-induced pain (61 and 81% respectively; p<0.05) when administered to plant extract at the dose of 400mg/kg body weight as compared to control animals (25 and 40% respectively). Conclusion: Brassica campestris leaves may contain pharmacologically active constituents associated with antinociceptive potential and analgesic effects in rats. The further characterization of those active moieties may be valuable for the treatment of pain and for designing a new analgesic strategy.

10aAnalgesic potential10aBrassica campestris10aFolk medicine10aFormalin-induced pain10aHot-plate test10aThermal hyperalgesia1 aAlzahrani, Abdullah, R1 aShahid, Imran uhttps://phcogres.com/article/2022/14/3/105530pres14343