02410nas a2200217 4500008004100000245013900041210006900180260001800249300000900267490000700276520169600283653001301979653002401992653001202016653001502028653001802043100002502061700002202086700002402108856006002132 2022 eng d00aPreliminary Assessment of Glycemic Control and Body Fat Reduction Effects of Terminalia chebula Retz. Extract on Pre-diabetic Subjects0 aPreliminary Assessment of Glycemic Control and Body Fat Reductio cDecember 2021 a5-110 v143 a

Background: Terminalia chebula Retz. (Combretaceae) is a medicinal herb using in traditional medicine worldwide and has hypoglycemic effects in animal models. Objectives: The present study was a double-blind, placebo-controlled trial designed to study the effect of T. chebula fruit water extract (TFWE) in pre-diabetic subjects. The efficacy of TFWE and placebo were compared in terms of reducing fasting blood sugar (FBS) levels, body mass indexes (BMI), body circumferences and skinfold thicknesses. Adverse events of TFWE intervention were also investigated. Materials and Methods: TFWE was phytochemically quantitated by HPLC analysis and its inhibitory action on alpha-glucosidase. In a clinical study, 80 pre-diabetic healthy subjects were classified according to BMI as normal weight and overweight and each group was further divided into 2 groups. The treatment group received 2 capsules of TFWE 500 mg, 2 times per day, before meals for 8 weeks and the control group received 2 placebo capsules, taken orally as the treatment group. Data was collected at week 0, 4 and 8 of the study. Results: For overweight participants receiving TFWE, the mean FBS levels were significantly lower than that of the placebo group (p = 0.026) at week 8. Visceral fat levels also showed a significant reduction (p = 0.039) compared to the placebo group. TFWE dispensation did not show serious adverse events. Conclusion: The administration of 2,000 mg TFWE per day was considered safe for the pre-diabetic healthy subjects with benefits in obesity management.

10aDiabetes10aFasting blood sugar10aObesity10aTerminalia10aVisceral fat.1 aSombattera, Sansanee1 aSungthong, Bunleu1 aRinthong, Prasoborn uhttps://phcogres.com/fulltext/v14i1/105530pres1412.html