@article {72, title = {Ghanaian Herbal Medicines for Malaria: An Evaluation of the Clinical Safety and Effectiveness of {\textquotedblleft}Time Herbal Mixture{\textquotedblright} in Uncomplicated Malaria}, journal = {Pharmacognosy Research}, volume = {12}, year = {2020}, month = {February 2020}, pages = {71-75}, type = {Original Article}, chapter = {71}, abstract = {

Background: Herbal antimalarials have become a popular source of treatment for most Ghanaians. The significant increase in patronage is of public health concern due to the lack of quality, safety, and efficacy data. Aim: In this report, we evaluated the clinical safety and effectiveness of a Ghanaian commercial product named {\textquotedblleft}Time Herbal Mixture{\textquotedblright} (THM). The product is formulated from the leaves of Solanum torvum and Vernonia amygdalina and the stem bark of Spathodea campanulata and Bombax buonopozense. Methods: Participants of 40 patients diagnosed with uncomplicated malaria were recruited, treated, and followed up for a period of 28 days. This population comprised 25 (62.50\%) females and 15 (37.50\%) males, with a mean age of 42.29 (12.35) years. Outcome of primary interest was the ability of the product to clear blood parasites by day 7 of the study, resolution of cardinal symptoms of malaria, and an absence of adverse effects from the use of the product. Results and Discussion: A total of 33 (82.50\%) participants achieved clearance of all parasites by day 7 (complete cure). Partial clearance was attained by 6 (15.0\%) and treatment failure in 1 (2.50\%). Resolution of the cardinal symptoms was also observed in most participants by day 7. The product also had a good safety profile as none of the participants reported any adverse effects. Liver, kidney, and hematological profiles were also normal after the study. Conclusion: {\textquotedblleft}THM,{\textquotedblright} therefore, has the potential to be used in cases of uncomplicated malaria.

}, keywords = {Bombax buonopozense, Clinical studies, Herbal antimalarials, Solanum torvum, Spathodea campanulata, Vernonia amygdalina}, doi = {10.4103/pr.pr_23_19}, author = {Andrews W Tetteh and Kwesi P Thomford and Merlin L Mensah and Kwame O Boadu and Ama K Thomford and Isaac K Amposah and Godfred Amofa and Benard K Turkson and Michael O Agyemang and Emmanuel DJ Owusu-Ansah} } @article {451, title = {Review of clinical studies of Polygonum multiflorum Thunb. and its isolated bioactive compounds}, journal = {Pharmacognosy Research}, volume = {7}, year = {2015}, month = {June,2015}, pages = {225-236}, type = {Review article}, chapter = {225}, abstract = {

Polygonum multiflorum Thunb. (PMT), officially listed in the Chinese Pharmacopoeia, is one of the most popular perennial Chinese traditional medicines known as He shou wu in China and East Asia, and as Fo-ti in North America. Mounting pharmacological studies have stressed out its key benefice for the treatment of various diseases and medical conditions such as liver injury, cancer, diabetes, alopecia, atherosclerosis, and neurodegenerative diseases as well. International databases such as PubMed/Medline, Science citation Index and Google Scholar were searched for clinical studies recently published on P. multiflorum. Various clinical studies published articles were retrieved, providing information relevant to pharmacokinetics-pharmacodynamics analysis, sleep disorders, dyslipidemia treatment, and neurodegenerative diseases. This review is an effort to update the clinical picture of investigations ever carried on PMT and/or its isolated bio-compounds and to enlighten its therapeutic assessment.

}, keywords = {Clinical pharmacokinetics, Clinical studies, Herbal hepatotoxicity, Polygonum multiflorum Thunb., Therapeutic assessment.}, doi = {10.4103/0974-8490.157957}, author = {Guy-Armel Bounda and Feng YU} }