@article {1465, title = {Antioxidant, Stimulating Telomerase and Anxiolytic Activities of Polysaccharide Isolated from Sargentodoxa cuneata}, journal = {Pharmacognosy Research}, volume = {17}, year = {2025}, month = {June 2025}, pages = {1020-1028}, type = {Original Article}, chapter = {1020}, abstract = {

Background: The classic anxiolytics have adverse effects in the treating anxiety disorders. Aim: To identify the anxiolytic polysaccharide from Sargentodoxa cuneata. Materials and Methods: The water-soluble Polysaccharide Fraction (PSC) was purified from S. cuneata, as well as its subfractions PSCA-1 and PSCB-1. The antioxidant effect of PSC against rotenone induced PC12 cell excitotoxicity, stimulating telomerase effect in HEK293T cell and anxiolytic effect on zebrafish were evaluated. Results: The pretreatment of PC12 with PSC obviously increased cell survival and SOD level. PSC also down-regulated the LDH release, ROS level and cell apoptosis rate. PSC promoted the 293T cell proliferation, associated with the mechanism of stimulating telomerase. Additionally, PSC alleviated the anxiety level in zebrafish induced by mCPP. Conclusion: These findings suggested that the PSC could possess the anxiolytic potential via antioxidant and telomerase activation.

}, keywords = {Antioxidant, Anxiety, Polysaccharide, Sargentodoxa cuneata, Telomerase}, doi = {10.5530/pres.20252269}, author = {Jian Tang and Ping Zhou and Huifang Sun and Xiuquan Xu and Chongwei Wen and Haiping Xia} } @article {1011, title = {Preventive Effects of Ginger Extract and Nigella sativa Oil on Anxiety and Depression Behavior in Wistar Rats Exposed to Mercuric Chloride}, journal = {Pharmacognosy Research}, volume = {14}, year = {2022}, month = {December 2021}, pages = {1-4}, type = {Original Article}, chapter = {1}, abstract = {

Background: Mercuric chloride (HgCl2) is toxic to humans and animals, and usually causes systemic and nerve damage. Aim: The aim of this study is to evaluate the neuro-protective effects of two medicinal plants rich in antioxidants against mercuric chloride poisoning in Wistar rats. Materials and Methods: This is an experimental study conducted on twenty-five adult rats randomly divided into five groups of five rats each, the untreated control group and the four groups are treated daily with Ginger extract (500 mg/kg/day) and Nigella sativa oil (2ml/kg/day) for four weeks. The administration of mercuric chloride (4mg/kg/day) will be from the second week of experimentation to three weeks. Results: The results obtained showed by behavioral tests that the administration of inorganic mercury (HgCl2) significantly increases the state of anxiety and depression of rats compared to control rats, while the groups pre-treated with antioxidants can reduce the damage of these behavioral disorders. Conclusion: Ginger extract and Nigella sativa oil have a very important role in neurobehavioral alterations induced by mercury toxicity.

}, keywords = {Antioxidants, Anxiety, Depression, Mercuric Chloride, Neuroprotection, Wistar Rats.}, doi = {10.5530/pres.14.1.1}, url = {https://phcogres.com/fulltext/v14i1/105530pres1411.html}, author = {Sabri Benkermiche and Samir Djemli and Meriem Haloui and Mohamed Lamine Benabed and Abdelkrim Tahraoui} } @article {278, title = {Effect of UP165, a Zea mays Leaf Extract Standardized for 6-methoxybenzoxazolinone, as Sleep Adjunct}, journal = {Pharmacognosy Research}, volume = {10}, year = {2018}, month = {April 2018}, pages = {156-160}, type = {Original Article}, chapter = {156}, abstract = {

Background: Sleep is a natural phenomenon essential for rejuvenating the body, promoting good health, upholding memory, performance, and maintaining overall health. Its deprivation is linked to the increased health risk that leads to poor quality of life and negative socioeconomic consequences. While behavioral techniques, such as improving sleep hygiene, are typically the first-line of intervention, pharmaceutical drugs are frequently used as adjuncts. However, for most, besides being too expensive, the long-term use of these drugs is marred by their severe adverse side effects and crippling dependency. As a result, significant numbers of patients are always in search for a safe and efficacious alternative from natural sources. Materials and Methods: We evaluated the effects of UP165, a Zea mays (commonly known as corn) leaf extract standardized for 6-methoxybenzoxazolinone content, on sleep latency and sleep time in pentobarbital-induced mouse sleep model. The extract was orally administered at 250 mg/kg (low dose), 500 mg/kg (mid dose), and 1000 mg/kg (high dose) daily for 32 days. The immediate impact of the extract on sleep was also assessed. Results: Increases of 11.6 {\textpm} 0.2 (P = 0.008), 10.2 {\textpm} 2.4 (P = 0.022), and 10.5 {\textpm} 0.9 (P = 0.017) minutes in sleep time were observed for the 250, 500, and 1000 mg/kg UP165 treated mice compared to vehicle control, respectively. Up to 67\% sleep latency incidence was observed for mice treated with UP165 compared to the 20\% in the vehicle control group. UP165 showed no immediate drowsiness effect. No differences in baseline and end of study bodyweight were observed between groups. Conclusion: UP165 could be used as an adjunct for a sleep disorder.

}, keywords = {6-methoxybenzoxazolinone, Anxiety, Sleep disorder, Stress, Zea mays}, doi = {10.4103/pr.pr_148_17}, author = {Mesfin Yimam and Ping Jiao and Mei Hong and Lidia Brownell and Qi Jia} } @article {376, title = {Effect of Beta vulgaris Linn. Leaves Extract on Anxiety- and Depressive-like Behavior and Oxidative Stress in Mice after Acute Restraint Stress}, journal = {Pharmacognosy Research}, volume = {8}, year = {2016}, month = {December 2015}, pages = {1-7}, type = {Original Article}, chapter = {1}, abstract = {

Background: Stress plays a significant role in the pathogenesis of neuropsychiatric disorders such as anxiety and depression. Beta vulgaris is commonly known as {\textquotedblleft}beet root{\textquotedblright} possessing antioxidant, anticancer, hepatoprotective, nephroprotective, wound healing, and anti-inflammatory properties. Objective: To study the protective effect of Beta vulgaris Linn. ethanolic extract (BVEE) of leaves against acute restraint stress (ARS)-induced anxiety- and depressive-like behavior and oxidative stress in mice. Materials and Methods: Mice (n = 6) were pretreated with BVEE (100 and 200 mg/kg, p. o.) for 7 days and subjected to ARS for 6 h to induce behavioral and biochemical changes. Anxiety- and depressive-like behavior were measured by using different behavioral paradigms such as open field test (OFT), elevated plus maze (EPM), forced swim test (FST), and tail suspension test (TST) 40 min postARS. Brain homogenate was used to analyze oxidative stress parameters, that is, malondialdehyde (MDA) and reduced glutathione (GSH) level. Results: BVEE pretreatment significantly (P \< 0.05) reversed the ARS-induced reduction in EPM parameters, that is, percentage entries and time spent in open arms and in OFT parameters, that is, line crossings, and rearings in mice. ARS-induced increase in the immobility time in FST and TST was attenuated significantly (P \< 0.05) by BVEE pretreatment at both the dosage. An increase in MDA and depletion of GSH level postARS was prevented significantly (P \< 0.05) with BVEE pretreatment at both the dosage (100 and 200 mg/kg). Conclusion: BVEE exhibits anxiolytic and antidepressant activity in stressed mice along with good antioxidant property suggesting its therapeutic potential in the treatment of stress-related psychiatric disorders.

}, keywords = {Acute restraint stress, Antioxidant, Anxiety, Beta vulgaris, Depression, Oxidative stress}, doi = {10.4103/0974-8490.171100}, author = {Kunjbihari Sulakhiya and Vikas Kumar Patel and Rahul Saxena and Jagrati Dashore and Amit Kumar Srivastava and Manoj Rathore} }