@article {1440, title = {Pharmacological Investigation of Actinidia deliciosa Extract in NSAIDs Induced Gastric Ulcer in Rodent Model}, journal = {Pharmacognosy Research}, volume = {17}, year = {2025}, month = {June 2025}, pages = {801-815}, type = {Review Article}, chapter = {801}, abstract = {

NSAIDs or non opoidal agents are commonly employed to treat rubor, dolor, relieve pain, but they often cause Gastrointestinal (GI) side effects, including gastritis, ulceration and bleeding. Natural products have emerged as potential alternatives or adjuncts to conventional treatments. The purpose of this study is to look at how Actinidia deliciosa (kiwi) extract protects against gastric ulcer brought on by NSAIDs. Background: NSAIDs are a group of pharmaceutical medications that are usually employed to treat rubor and dolor along with pyrexia as well as give a certain analgesic action at a certain therapeutic dose. At certain doses it is also used treat some sort of discomfort. While effective for these purposes, NSAIDs can also cause significant Gastrointestinal (GI) side effects, leading to conditions like gastritis, ulcers and even bleeding. This condition is known as NSAIDs-induced gastric ulcer. Materials and Methods: Rats will be divided into control, NSAIDs-induced gastric ulcer and NSAIDs-induced gastric ulcer treated with Actinidia deliciosa extract groups. The NSAIDs-induced gastric ulcer model will be established using indomethacin. The extract will be administered orally at various doses for a specified duration. GI damage will be assessed by measuring ulcer index, histological examination and biochemical markers (e.g., myeloperoxidase, malondialdehyde). The antioxidant activity of the extract will also be evaluated. Results: Preliminary findings suggest that Actinidia deliciosa extract significantly reduces NSAIDs-induced GI damage. It may exert its protective effects through antioxidant properties, inhibition of inflammatory mediators and mucosal barrier enhancement. Conclusion: Actinidia deliciosa extract shows promise as a potential natural agent for preventing NSAIDs-induced gastric ulcer. Further studies are warranted to elucidate the underlying mechanisms, determine the optimal dosage and administration route.

}, keywords = {Actinidia deliciosa, Antioxidant, Diclofenac, Gastric ulcer, Gastric ulcers, NSAIDs}, doi = {10.5530/pres.20252087}, author = {Arijit Chaudhuri and Arushi A and Manisha Dhiman and Anshul Thakur and Risha Kumari and Seema Devi and Shilpa Thakur and Ayusha A and Prince P and Nidhika N} } @article {274, title = {Protective Effect of Struthanthus marginatus on Ethanol-induced Gastric Damage in Mice}, journal = {Pharmacognosy Research}, volume = {10}, year = {2018}, month = {April 2018}, pages = {143-150}, type = {Original Article}, chapter = {143}, abstract = {

Background: Our research group previously characterized the antioxidant and gastroprotective effects of Struthanthus marginatus (Loranthaceae), a medicinal herb used in Brazil as a healing agent. Objective: The aim of this study is to evaluate the chemical composition of aqueous extract of S. marginatus (AESm), as well as the mechanisms underlying its gastroprotective and ulcer healing properties using different protocols in mice. Materials and Methods: Gas chromatography-mass spectrometry and liquid chromatography/electrospray ionization-mass spectrometry-mass spectrometry/diode array detection analyses to evaluate the chemical composition of AESm were conducted. The antisecretory activity (basal or stimulated) was determined using the pyloric ligature method. The gastroprotective action of nitric oxide and sulfydryl groups ({\textendash}SH groups) were evaluated using ethanol-induced gastric ulcer model. The healing ability was evaluated using an acetic acid-induced chronic ulcer. Results: Chromatographic analyses of AESm permitted to identify several compounds, including 3-trans-caffeoylquinic acid (3-trans-CGA), quercetin, and kaempferol as the major constituents. Oral treatment of animals with AESm (500 mg/kg/day) reduced the severity of ethanol-induced gastric damage similar to omeprazole and in a more pronounced manner than 3-trans-CGA. Such effect was significantly reduced in animals pretreated with Nω-nitro-L-arginine methyl ester. In addition, AESm inhibited gastric acid secretion in pylorus-ligated mice stimulated with histamine or pilocarpine similar to atropine or cimetidine, respectively. A decrease in acetic acid-induced gastric ulcers similar to that promoted by cimetidine was also observed. Conclusion: The results show that S. marginatus is rich in flavonoids and that these compounds contribute directly to the gastroprotective and ulcer healing effects of this herb. The inhibition of gastric secretion is the possible gastroprotective mechanism.

}, keywords = {Antiulcer activity, Gastric ulcers, Herbal medicine, Struthanthus marginatus}, doi = {10.4103/pr.pr_76_17}, author = {S{\^o}nia Maria de Farias Freire and R{\^o}mulo Vieira Silva and T{\'a}bata Maira Freitas Morais and Rachel Melo Ribeiro and Selma do Nascimento Silva and Maria do Socorro de Sousa Cart{\'a}genes and Iracelle Carvalho Abreu and Maria Nilce de Sousa Ribeiro and Danilo da Cruz Centeno and Luce Maria Brand{\~a}o Torres and Marilene Oliveira da Rocha Borges and Antonio Carlos Rom{\~a}o Borges} }