@article {1370, title = {Effect of a Thermogenic Composition on Healthy Adult Women and Men in a 12-Week Weight Management Study}, journal = {Pharmacognosy Research}, volume = {17}, year = {2025}, month = {January 2025}, pages = {100-107}, type = {Original Article}, chapter = {100}, abstract = {

Background: Weight loss medications can have severe side effects and thus there is a need to identify safe and effective alternative treatments. Dietinduced thermogenesis and a potential stimulation of fat metabolism might be achieved by consumption of certain foods. Objectives: The aim of the present study was to explore the effects of a Thermogenic Composition (TC) composed of dihydrocapsiate, red pepper (Capsicum annuum), citrus (Citrus spp.) peel extract, Coleus forskohlii and African mango (Irvingia gabonensis) to support body composition, weight management and improve satiety in healthy adults. Methods: Thirty-six participants were instructed to take TC daily over a 12-week interval. Body composition, energy levels, feelings of hunger and satiety were measured. Results: Body Fat percentage showed significant reduction at week 7 and 12 compared to week 0. Waist to Hip Ratio results showed significant reduction at week 7 compared to week 0. Feelings of Hunger and Feelings of Fullness showed significant improvement at week 3, 7 and 12 compared to week 0. Desire to Eat showed a significant reduction at week 3,7 and 12 compared to week 0. Appetite showed significant reduction at week 7 and 12 compared to week 0. Conclusion: TC showed significant improvements in hunger cravings and feelings of fullness as well as significant reduction in percent body fat and waist to hip ratio. The good safety and tolerability profile of TC supported its use as a daily nutritional supplement for weight management and body composition.

}, keywords = {African mango (Irvingia gabonensis), Citrus (Citrus spp) peel extract, Coleus forskohlii, dihydrocapsiate, Red pepper (Capsicum annuum), Thermogenesis}, doi = {10.5530/pres.20251936}, author = {Millerlandy Popayan Jaramillo and David Vollmer and Xuesheng Han} } @article {192, title = {Anticataract Activity of Forskolin by Inhibiting Polyol Pathway for the Prevention of Diabetic Complication}, journal = {Pharmacognosy Research}, volume = {11}, year = {2019}, month = {November,2019}, pages = {352-355}, type = {Original Article}, chapter = {352}, abstract = {

Background: Cataract is the opacification or optical dysfunction of the crystalline lens. Diabetes has been considered to be one of the major risk factors of cataract. Objective: The present study was designed to evaluate the anticataract activity of antioxidants such as Coleus forskohlii (CF) Briq and its phytoconstituent forskolin (FS) which were subjected to prevent cataract formation in vitro on glucose-induced cataract model. Materials and Methods: Goat lenses were incubated in Krebs-Ringer bicarbonate buffer pH 7.5 (supplemented with Taxim and streptomycin) containing 55 mM glucose (cataractogenesis) with fidarestat; CF methanolic extract; and FS at a concentration of 1 {\textmu}g/mL, 100 {\textmu}g/mL, and 10 {\textmu}g/mL for 24 hr at 37{\textdegree}C with 5\% CO2 and 95\% air. Glucose-induced opacification of goat lens began 8{\textendash}10 hr\ after incubation and was complete in 24 hr. Polyol (galactitol) levels in incubated lenses were estimated spectrophotometrically. Results: Cataractous lenses showed higher content of galactitol. However, lens treated with fidarestat, CF methanolic extract, and its phytoconstituent FS showed lower content of galactitol. Conclusion: CF and FS prevented the formation and progress of cataract by glucose, as evidenced by lens transparencies with photographic evaluation and lens galactitol levels.

}, keywords = {Aldose reductase, Cataract, Coleus forskohlii, Forskolin, Polyol pathway.}, doi = {10.4103/pr.pr_68_19}, author = {Damera Sujatha and Ajmera Rama Rao and Ciddi Veeresham} } @article {455, title = {Extraction and Elemental Analysis of Coleus forskohlii Extract}, journal = {Pharmacognosy Research}, volume = {7}, year = {2015}, month = {June,2015}, pages = {237-241}, type = {Original Article}, chapter = {237}, abstract = {

Background: Coleus forskohlii Willd. is a popular traditional medicine used since ancient times for treatment of heart diseases, abdominal colic and respiratory disorders. Objectives: The aim of this study was to characterize the root extract of the medicinal plant Coleus forskohlii. Materials and Methods: Dry roots of C. forskohlii were used to extract Forskolin using toluene as a solvent. Thus, obtained extract of C. forskohlii was standardized to 30\% and used for further studies. Results: The physical properties of the extract were analyzed through scanning electron microscopy analysis, while the characterization of root extract through X-ray diffraction (XRD) and element analysis. The morphological feature of the C. forskohlii extract showed a flake like structure and the XRD showed sulfur trioxide (SO3) and trimer of sulfur trioxide (S3O9). Through element analysis, elements such as carbon, oxygen, magnesium, aluminum, silicon, phosphorous, and sulfur were identified. Carbon showed the highest weight of 75.49\% in comparison to all other elements.

}, keywords = {Coleus forskohlii, element analysis, Physical properties, Scanning electron microscope, X-Ray diffraction.}, doi = {10.4103/0974-8490.157966}, author = {Haritha Kanne and Narayan Pandurang Burte and V. Prasanna, Ravi Gujjula} } @article {699, title = {Effect of Coleus Forskohliiextract on Cafeteria Diet-induced Obesity in Rats}, journal = {Pharmacognosy Research}, volume = {6}, year = {2014}, month = {December,2013}, pages = { 42-45}, type = {Original Article}, chapter = { 42}, abstract = {

Background: Obesity is a metabolic disorder that can lead to adverse metabolic effects on blood pressure, cholesterol, triglycerides and insulin resistance and also increases the risk of coronary heart disease, ischemic stroke and type 2 diabetes mellitus. This study was designed to determine the effect of Coleus forskohlii on obesity and associated metabolic changes in rats fed with cafeteria diet. Objective: The aim of this study was to evaluate antiobesogenic and metabolic benefits of C. forskohlii in cafeteria diet induced obesity rat model. Materials and Methods: Rats were randomly divided into five groups of six animals in each group and as follows: Normal pellet diet group; cafeteria diet group; cafeteria diet followed by 50 mg/kg/d Coleus forskohlii extract (CFE), 100 mg/kg/d CFE and 45 mg/kg/d orlistat groups, respectively. Indicators of obesity such as food intake, body weight and alteration in serum lipid profiles were studied. Results: Feeding of cafeteria diet induced obesity in rats. Administration of CFE significantly halted increase in food intake and weight gain associated with cafeteria diet. Development of dyslipidemia was also significantly inhibited. Conclusion: The observed effects validate that supplementation of CFE with cafeteria diet could curb the appetite and mitigate the development of dyslipidemia.

}, keywords = {Appetite, Cafeteria diet, cholesterol, Coleus forskohlii, Lipid profile}, doi = {10.4103/0974-8490.122916}, author = {Hebbani Nagarajappa Shivaprasad and Sushma Gopalakrishna and Bhanumathy Mariyanna and Midhun Thekkoot and Roopa Reddy and Boreddy Shivanandappa Tippeswamy} }