@article {1356, title = {Design and Evaluation of Novel in situ Gel Forming Ocular Drug Delivery System of Kaempferol for Sustain Pharmacological Response against Cataract}, journal = {Pharmacognosy Research}, volume = {17}, year = {2025}, month = {January 2025}, pages = {173-184}, type = {Original Article}, chapter = {173}, abstract = {

Aim: Cataract is an eye disease in which the lens of eyes becomes cloudy. It is a major source of blindness globally. As per the reports published by WHO, around 161 million people are visually compromised worldwide. No clinically proven drug is available to date for the cataract treatment and surgery is the only option left for the management of cataract Treatments other than surgery are just prevention based. Background: A major setback for the development of ocular medications is the poor bioavailability and low therapeutic response of available conventional ophthalmic solutions in the treatment of cataract due to the instant precorneal removal of the drug. Ophthalmic bioavailability of only 1-10\% is generally attained and to overcome this problem frequent installation of the concentrated drug solution is required with increases the systemic absorption of the drug through the nasolacrimal absorption of the drug. The in situ gel forming systems are special drug dosage form that when instilled in the eye as a drop undergoes a transitional change from solution form to the gel with a change in its environmental pH. Materials and Methods: In the present study, Kaempferol ophthalmic gel was prepared using polymers such as Pectin and HPMC K4M as a pH-triggered gelling system to increase contact time and controlled release, to decrease the rate of administration and upsurge the therapeutic efficacy of the drug. Formulation development involved selection of right polymers from plethora of polymers such as HPMC k4m, Pectin, Carbopol and tween 80 in different compositions. The required quantity of drug (1\%) soluble in ethanol was poured onto the polymeric solution and proper mixing was done. To evaluate the efficacy of the formulation developed, various methods were employed-clarity, pH, estimation of gelling capacity, gelling strength, viscosity, in vitro cumulative percent drug release. The composition that satisfies all the above-mentioned parameters, was selected as the optimized formulation and this formulation was used in the pharmacological evaluation of the drug. Results: The evaluation of the anti-cataract activity of Kaempferol was done by using the sodium selenite-induced cataract model in Wistar rat pups.

}, keywords = {Cataract, In situ gelling, Kaempferol, Ocular tension, Sustained Release}, doi = {10.5530/pres.20251969}, author = {Arijit Chaudhuri and Vinod Kumar Gauttam and Arushi A and Sumiran Negi and Gobind Singh and Bharti B and Swati Mishra and Sneha Sharma and Prince P and Aatiqa A and Neetu Sharma and Atul Rana and Divyanshu D} } @article {192, title = {Anticataract Activity of Forskolin by Inhibiting Polyol Pathway for the Prevention of Diabetic Complication}, journal = {Pharmacognosy Research}, volume = {11}, year = {2019}, month = {November,2019}, pages = {352-355}, type = {Original Article}, chapter = {352}, abstract = {

Background: Cataract is the opacification or optical dysfunction of the crystalline lens. Diabetes has been considered to be one of the major risk factors of cataract. Objective: The present study was designed to evaluate the anticataract activity of antioxidants such as Coleus forskohlii (CF) Briq and its phytoconstituent forskolin (FS) which were subjected to prevent cataract formation in vitro on glucose-induced cataract model. Materials and Methods: Goat lenses were incubated in Krebs-Ringer bicarbonate buffer pH 7.5 (supplemented with Taxim and streptomycin) containing 55 mM glucose (cataractogenesis) with fidarestat; CF methanolic extract; and FS at a concentration of 1 {\textmu}g/mL, 100 {\textmu}g/mL, and 10 {\textmu}g/mL for 24 hr at 37{\textdegree}C with 5\% CO2 and 95\% air. Glucose-induced opacification of goat lens began 8{\textendash}10 hr\ after incubation and was complete in 24 hr. Polyol (galactitol) levels in incubated lenses were estimated spectrophotometrically. Results: Cataractous lenses showed higher content of galactitol. However, lens treated with fidarestat, CF methanolic extract, and its phytoconstituent FS showed lower content of galactitol. Conclusion: CF and FS prevented the formation and progress of cataract by glucose, as evidenced by lens transparencies with photographic evaluation and lens galactitol levels.

}, keywords = {Aldose reductase, Cataract, Coleus forskohlii, Forskolin, Polyol pathway.}, doi = {10.4103/pr.pr_68_19}, author = {Damera Sujatha and Ajmera Rama Rao and Ciddi Veeresham} }