@article {1175, title = {In vivo Investigation to Validate the Traditional Usage of Sorbaria tomentosa (Lindley) Reh. Root Extract against Alloxan-induced Diabetic Rats}, journal = {Pharmacognosy Research}, volume = {15}, year = {2023}, month = {October 2023}, pages = {671-678}, type = {Original Article}, chapter = {671}, abstract = {

Background: DM is a complicated condition that impacts the handling of sugar, fat, and protein metabolism in our bodies. Medicinal herbs play a significant role in diabetes care. As a result, we focused on the plant components traditionally employed by regional medical professionals. Objectives: The current research was carried out to check if Sorbaria tomentosa (Lindley) Reh. (ST) the ethanolic root extracts anti-diabetic potential. ST is a member of the Rosaceae family commonly known by the common name "false spirae." The root extract of ST is used by the locals in the Kinnaur district of Himachal Pradesh to effectively treat diabetes. Materials and Methods: Plant ethanolic extracts were evaluated for their potential on alloxan-induced diabetic rats for 14 days. The animals were put into one of four treatment groups at random: a normal control group, not treated diabetic control group (150 mg/kg bw), a drug control group that got glibenclamide (5 mg/kg bw), and the last treatment group medicated with ST root extract (50 mg/kg BW). Liver, pancreas, and kidney histopathology were analyzed to correlate biochemical findings with histological changes. Results: Our results showed that the extract and medication-treated diabetic groups gained statistically significant weight (p<=0.001) and that their BGL went back to normal. Along with more common biological markers such as SGOT, SGPT, ALP, TC, TG, HDL, LDL, VLDL, creatinine level, uric acid, urea, and uric acid were measured. After the extract treated hyperglycaemic rats, all biochemical markers came under the normal range (p<=0.001). Improvement of the damaged structure of the liver, pancreas, and kidneys was observed after treatment with standard medication and root extracts of ST. Conclusion: Based on the data gathered from the tribal research area, to the best of our capacity, we have uncovered for the very first time the anti-diabetic efficacy of the plant parts. The empirical knowledge of previous generations is typically the basis for the traditional utilization of medicinal plants for controlling diabetes. Nevertheless, in vivo, research has assisted to discover the anti-diabetic potential of ST{\textquoteright}s ethanolic root extract and provides scientific proof to back up these claims. The plant component may also be used to create natural antidiabetic drugs that are effective.

}, keywords = {Alloxan, Diabetes mellitus, Kinnaur, Sorbaria tomentosa, Traditional knowledge, Wistar rats}, doi = {10.5530/pres.15.4.071}, author = {Monika Mehta and Richa Puri and Dechan Angmo and Pooja Boora and Sushila Rani} } @article {169, title = {Effect of Carbon Tetrachloride-induced Hepatic Injury on Luffa acutangula (var.) Amara}, journal = {Pharmacognosy Research}, volume = {12}, year = {2020}, month = {August 2020}, pages = {278-284}, type = {Original Article}, chapter = {278}, abstract = {

Objectives: To study the reversal effect of carbon tetrachloride (CCl4)-induced hepatic injury on the ethyl acetate and ethanol extracts of Luffa acutangula var. amara in Wistar rats. Materials and Methods: The study included experimental mice groups in which pentobarbital-induced sleeping time and its prolongation by CCl4 is assessed by righting reflex and recovery time. Chronic liver injury was induced by oral administration of CCl4 and acute injury by a single intraperitoneal injection in experimental Wistar rats. Blood and liver specimens were used for analysis of enzymatic reactions. Results: It was noted that the mice groups treated with extracts decrease the sleeping time in and standard silymarin than the control group. Acute and chronic liver injury models showed increases in total protein and glutathione peroxidase, whereas there was a reduction in total bilirubin and serum alkaline phosphate level in extracts and standard silymarin-treated rats than control. Histopathological studies showed a significant reduction in inflammation, fatty change and gross necrosis in extracts and standard silymarin-treated animals than control. Conclusion: The study suggests that extracts of L. acutangula var. amara can be useful in treating acute and chronic hepatic injury.

}, keywords = {Aspartate aminotransferase, Carbon tetrachloride, Hepatoprotective, Luffa acutangula, Silymarin, Wistar rats}, doi = {10.4103/pr.pr_113_19}, author = {E Prabhu Daniel and AR Vijayakumar and W Clement Atlee and R Ilavarasan and M Sivakumar} } @article {481, title = {Ulcer Protective Activity of Jatropha gossypiifolia Linn. in Wistar Rats}, journal = {Pharmacognosy Research}, volume = {8}, year = {2016}, month = {March 2016}, pages = {61-66}, type = {Original Article}, chapter = {61}, abstract = {

Background: Several synthetic drugs are useful in the treatment of peptic ulcer, but almost of these drugs are used in prolonging time, it may cause several adverse reactions. However, the herbal medicines are more potent to the treatment and minimize the side effects. Objective: To evaluate the methanol extract of Jatropha gossypiifolia Linn. (MEJG) for gastro protective activity against Wistar rats. Materials and Methods: Anti-ulcer potency of MEJG (100 and 200 mg/kg, b.w.) was assessed using aspirin (200 mg/kg, p.o.) plus pylorus ligation ulcer model and the parameters studied were ulcer index (UI), gastric juice volume, pH, total acidity, and total acid output. Same extract was studied by ethanol-induced (80\%, 5 mL/kg, intragastrically) ulcer model, and the UI and biochemical parameters were studied. Results: The oral administration of MEJG (100 and 200 mg/kg) significantly (P \< 0.001) attenuated the ulcer score and anti-secretary parameters (such as the volume of gastric content, free acidity, total acidity, and total acid output) in the aspirin plus pylorus ligation rats. The extract also significantly attenuated (P \< 0.001) ulcer score in ethanol-induced ulcer model and lipid peroxidation level and significantly increased the level of glutathione peroxides, catalase, and superoxide dismutase activity. The MEJG may possess active constituents such as alkaloids, glycosides, flavonoids, and terpenes, which may play a major role in gastroprotective effect in Wistar rats. Conclusion: The present study provides scientific support for the anti-ulcer activities of extracts of JG and also claimed that antioxidant potential of the extracts. However, substantiates the traditional claims for the usage of this drug in the treatment of gastric ulcer.

}, keywords = {Antioxidant enzymes, anti-ulcer, Aspirin, ethanol, jatropha gossypiifolia, ranitidine, Wistar rats}, doi = {10.4103/0974-8490.178640}, author = {Arumugam Ramamoorthy Vijayakumar and Epison Prabu Daniel and Raju Ilavarasan and S. Venkataraman and S. Vijayakumar} } @article {465, title = {In vivo anti-inflammatory and Antiarthritic Activities of Aqueous Extracts from Thymelaea Hirsuta,}, journal = {Pharmacognosy Research}, volume = {7}, year = {2015}, month = {June 2015}, pages = {213-216}, type = {Short Communication }, chapter = {213}, abstract = {

Background:\ The aerial parts of\ Thymelaeahirsuta\ (TH) are used as a decoction in the treatment of different pathologies in folk medicine in Morocco.\ Objective:\ The aqueous extracts were evaluated for its anti-inflammatory activity and in inhibition of adjuvant induction arthritis in male Wistar rats.\ Materials and Methods:\ The anti-inflammatory activity was carried out using carrageenan-induced rat paw edema model, and the antiarthritic activity was carried out using complete Freund{\textquoteright}s adjuvant-induced arthritis model.\ Results:\ The plant extract (500 mg/kg body weight) exhibited significant activity in acute inflammation produced 60\% of inhibition after 4 h as compared with that of the standard anti-inflammatory drug, the diclofenac (100 mg/kg) which showed 40\% of inhibition. In arthritis model, the extract produced 85\% inhibition after 18 days when compared with the diclofenac (10 mg/kg; 72\%).\ Conclusion:\ These results indicate that the aqueous extract of TH had an anti-inflammatory activity and inhibited the induction of adjuvant arthritis in male Wistar rats.

}, keywords = {Antiarthritis, Antiinflammation, Medicinal plants, Thymelaea hirsuta, Wistar rats}, doi = {10.4103/0974-8490.150510 }, author = {Zora Azza and Mounia Oudghiri} }