@article {169, title = {Effect of Carbon Tetrachloride-induced Hepatic Injury on Luffa acutangula (var.) Amara}, journal = {Pharmacognosy Research}, volume = {12}, year = {2020}, month = {August 2020}, pages = {278-284}, type = {Original Article}, chapter = {278}, abstract = {

Objectives: To study the reversal effect of carbon tetrachloride (CCl4)-induced hepatic injury on the ethyl acetate and ethanol extracts of Luffa acutangula var. amara in Wistar rats. Materials and Methods: The study included experimental mice groups in which pentobarbital-induced sleeping time and its prolongation by CCl4 is assessed by righting reflex and recovery time. Chronic liver injury was induced by oral administration of CCl4 and acute injury by a single intraperitoneal injection in experimental Wistar rats. Blood and liver specimens were used for analysis of enzymatic reactions. Results: It was noted that the mice groups treated with extracts decrease the sleeping time in and standard silymarin than the control group. Acute and chronic liver injury models showed increases in total protein and glutathione peroxidase, whereas there was a reduction in total bilirubin and serum alkaline phosphate level in extracts and standard silymarin-treated rats than control. Histopathological studies showed a significant reduction in inflammation, fatty change and gross necrosis in extracts and standard silymarin-treated animals than control. Conclusion: The study suggests that extracts of L. acutangula var. amara can be useful in treating acute and chronic hepatic injury.

}, keywords = {Aspartate aminotransferase, Carbon tetrachloride, Hepatoprotective, Luffa acutangula, Silymarin, Wistar rats}, doi = {10.4103/pr.pr_113_19}, author = {E Prabhu Daniel and AR Vijayakumar and W Clement Atlee and R Ilavarasan and M Sivakumar} } @article {253, title = {Methanol Extract of Adansonia digitata Leaf Protects Against Sodium Arsenite-induced Toxicities in Male Wistar Rats}, journal = {Pharmacognosy Research}, volume = {9}, year = {2017}, month = {February 2017}, pages = {7-11}, type = {Original Article}, chapter = {7}, abstract = {

Background: Human and animal population exposure to arsenic through the consumption of arsenic contaminated water is rampant in many parts of the world. Protective agents of medicinal plants origin could provide maximum protection against toxicities of various kinds. Objective: The protective role of orally administered methanol extract of the leaves of Adansonia digitata (MELAD) on sodium arsenite (SA) - induced clastogenicity and hepatotoxicity in male Wistar rats was evaluated. Materials and Methods: Thirty male Wistar rats divided into six Groups (1{\textendash}6) of five animals each were used for the study. Group 1 (negative control) received distilled water and normal diet only, Groups 2{\textendash}6 received the extract (at 250 or 500 mg/kg body weight) and/or SA at 2.5 mg/kg body weight. Results: There was statistically significant (P \< 0.05) increase in the number of micronucleated polychromatic erythrocytes and lipid peroxidation in the SA group as compared with the negative control and treated groups. Administration of the extract reduced the effects of SA on the above parameters. Activities of serum alanine and aspartate aminotransferases did not show statistically significant effects; however, the histological analyses revealed periportal cellular infiltration by mononuclear cells, whereas the MELAD treated groups show mild cellular infiltration and mild portal congestion. Conclusions: MELAD protect against SA-induced toxicities in rats, and it may offer protection in circumstances of co-exposure and cases of arsenicosis

}, keywords = {Adansonia digitata, Alanine aminotransferase, Aspartate aminotransferase, Number of micronucleated polychromatic erythrocytes}, doi = {10.4103/0974-8490.199768}, author = {Ayodeji Mathias Adegokex and Ayodeji Mathias Adegoke and Michael Adedapo Gbadegesin and Oyeronke Adunni Odunola} }