@article {155, title = {Antidiabetic and Antidyslipidemic Activities of Hexane/Ethyl Acetate/Methanol Fractions of Paspalum scrobiculatum Linn. Grains in High-Fat Diet and Streptozotocin-Induced Diabetic Rats}, journal = {Pharmacognosy Research}, volume = {12}, year = {2020}, month = {August 2020}, pages = {230-235}, type = {Original Article}, chapter = {230}, abstract = {

Background: Dietary habits and sedentary lifestyle are the major causes of increasing obesity, which in turn causes diabetes and cardiovascular problems. With this alarming increase, there is a need for alternative therapies to treat diabetes and hyperlipidemia. Objectives: To evaluate antidiabetic and antidyslipidemic effects of fractions of Paspalum scrobiculatum grains in rats. Materials and Methods: Different doses of Hexane: Ethyl acetate fraction of P. scrobiculatum (HEPS) and Ethyl acetate: Methanol fraction of P. scrobiculatum (EMPS) fractions of P. scrobiculatum were administered to the high-fat diet (HFD) and streptozotocin (STZ) (35 mg/ kg)-induced diabetic rats with glibenclamide at 20 mg/kg body weight (b.w) as a standard reference. Biochemical and histopathological changes were assessed after 5 weeks of treatment. Results: Daily oral treatment with HEPS and EMPS each at 100 and 200 mg/kg b.w for 5 weeks was found to be significant in the reduction of plasma glucose levels, HbA1c, increased plasma insulin levels, and normalized lipid profile and liver function parameters in HFD and STZ-induced diabetic rats. In addition, degenerative histopathological changes seen in liver, kidney, and pancreas of diabetic rats were found to be normalized in HEPS and EMPS as comparable to that of glibenclamide-treated rats. Conclusion: The obtained results suggest that HEPS and EMPS fractions of P. scrobiculatum grains possess promising antihyperglycemic and antidyslipidemic potential without apparent toxic effects, which may prove the claimed use of the plant in treatment of diabetes and dyslipidemia.

}, keywords = {Antidiabetic, Antidyslipidemic, High-fat diet, Paspalum scrobiculatum, Streptozotocin}, doi = {10.4103/pr.pr_6_20}, author = {G Jyothi Reddy and K Bhaskar Reddy and G V Subba Reddy} } @article {172, title = {Antilipidemic Properties of Calpurnia aurea Leaf Extract on High-Fat Diet Induced Hyperlipidemia}, journal = {Pharmacognosy Research}, volume = {11}, year = {2019}, month = {November,2019}, pages = {389-395}, type = {Original Article}, chapter = {289}, abstract = {

Background: Hyperlipidemia is described by raised in the plasma lipids including triglycerides (TG), cholesterols, cholesterol esters, phospholipids as well as plasma lipoproteins, for example, very low-density lipoprotein (LDL), LDL, and reduction in the circling high-density lipoprotein (HDL) levels. Objective: To explore the antilipidemic properties of the hydromethanolic extract of Calpurnia aurea (HMECA) leafs against high-fat diet-induced hyperlipidemic male albino Wistar rats. Materials and Methods: Thirty albino Wistar rats of 60{\textendash}75 days and weights of 150{\textendash}200 g were isolated arbitrarily into six groups of five each. Group I fed with normal diet in as typical control, Group II got high-fat-eating routine (48.8\% fat w/w) containing fat produced using hamburger fat and blended with hydrogenated vegetable oil, Group III fed with high fat diet plus 3.5 mg/kg/day atorvastatin as standard control, and the remaining Groups IV, V, and VI fed with high fat diet along with different does of HMECA at 200, 300, and 400 mg/kg/day separately for 60 days. Food intake, body weight, body mass index, serum lipid profiles, and liver histopathology were studied. Results: The results of this investigation exposed that HMECA has dose-dependent antilipidemic exercises. HMECA treatment of 400 mg/ kg caused a noteworthy bringing down of P \< 0.05 of serum LDL from 28.53 {\textpm} 12.2 mg/dl to 9.70 {\textpm} 5.77 mg/dL; the serum cholesterol level from 92.00 {\textpm} 13.0 mg/dl to 60.33 {\textpm} 8.60 mg/dl; the serum TG leve1 from 84.73 {\textpm} 19.4 mg/dl to 71.83 {\textpm} 13.0 mg/dl mg/dl; and increased the serum HDL-cholesterol levels from 11.66 {\textpm} 1.23 mg/dl to 29.66 {\textpm} 1.52 mg/dl. At the medium dosage of 300 mg/kg, it was not successful as 400 mg/ kg and at the insignificant dosage of 200 mg/kg brought numerical contrast not statistically noteworthy among the serum lipid profile. Conclusion: This research discovered that the HMECA possesses a significant antilipidimic activity in dose dependent manner. The molecular mechanism of antilipidemic exercises of this medication should be contemplated.

}, keywords = {Antilipidemia, Calpurnia aurea, High-fat diet, Hyperlipidemia, Lipid profile.}, doi = {10.4103/pr.pr_10_18}, author = {Welde Mengistu and Seifu Daniel and Natesan Gnanasekaran} }