@article {153, title = {Terminalia chebula Retz: A Prospective Agent in Reducing the Doxorubicin-Mediated Cardiotoxicity}, journal = {Pharmacognosy Research}, volume = {12}, year = {2020}, month = {August 2020}, pages = {219-224}, type = {Original Article}, chapter = {219}, abstract = {

Objectives: The present study evaluated the role of Terminalia chebula Retz. extract against doxorubicin (DXR)-mediated cardiac damages in male and female rats. Materials and Methods: The ethanolic extract of T. chebula (0.25, 0.5, and 1 g/kg) was administered simultaneously with DXR (2.5 mg/kg, three-doses on alternate days by intraperitoneal route). Two additional groups were evaluated by administering 0.5 g/kg of the extract to animals before or after DXR treatment. The study was done separately in male and female adult Wistar rats of bodyweight 180{\textendash}200 mg. The cardiac biomarker levels such as creatine kinase-monoenzyme B, lactate dehydrogenase, alanine aminotransferase, and aspartate aminotransferase were estimated after each treatment. Histopathology of cardiac tissue was studies analyzed, and the level of superoxide dismutase was determined in serum. The results were statistically analyzed using one-way ANOVA and Bonferroni tests and P \< 0.05 was considered to indicate the statistical significance. Results: The observations indicated that DXR significantly (P \< 0.001) elevated the biomarker levels of cardiac damage in both male and female rats, besides inducing the structural changes in the myocardium tissues and antioxidant status. The co-administration of higher doses of T. chebula extract (0.5 and 1 g/kg) with DXR significantly (P \< 0.01) reduced the cardiac enzyme levels and histopathological changes and improve the antioxidant status compared to DXR group. Post-treatment with T. chebula (0.5 mg/kg) showed mild inhibitory action on the DXR-induced cardiac changes without significantly affecting the antioxidant level. Conclusion: The results suggest that co-administration of T. chebula reduced the DXR-mediated cardiac damages and the action could be related to the enhancement of the antioxidant property in rats.

}, keywords = {Cardiac biomarkers, Doxorubicin, Oxidative stress, Terminalia chebula}, doi = {10.4103/pr.pr_109_19}, author = {M Aamina and Ahmad Alhowail and Maha Aldubayan and Syed Imam Rabbani} } @article {404, title = {Anti-Lipoxygenase Activity of Leaf Gall Extracts of Terminalia chebula (Gaertn.) Retz. (Combretaceae)}, journal = {Pharmacognosy Research}, volume = {8}, year = {2016}, month = {December 2015}, pages = {78-82}, type = {Short Communication}, chapter = {78}, abstract = {

Lipoxygenase (LOX) inhibitors are the promising therapeutic target for treating a wide spectrum of inflammatory-related diseases such as cancer, asthma, lymphoma, leukemia, and autoimmune disorders. In the present study, the photochemical constituents and the anti-LOX potential of leaf galls of Terminalia chebula are evaluated to exemplify its further potential development as medicine. Extracts of T. chebula galls were tested for anti-LOX activity using linoleic acid as substrate and lipoxidase as an enzyme and also the total content of polyphenols with phytochemical analysis of the extract were determined. The presence of highest total phenolic and flavonoid content of 141 {\textpm} 2.2 mg of gallic acid equivalent/g d.w and 125 {\textpm} 1.4 mg of quercetin equivalent/g d.w and maximal LOX inhibitory activity (52.67\%) at 800 μg/mL concentrations were identified in the ethanolic extracts of leaf galls of T.chebula. The higher LOX inhibitory activity was positively correlated to the high content of total polyphenols/flavonoids. The results of this study confirm the folklore use of T. chebula leaves gall extracts as a natural anti-inflammatory agent and justify its ethnobotanical use. Therefore, the results encourage the use of T. chebula leave gall extracts for medicinal health, functional food, and nutraceuticals applications.

}, keywords = {Antioxidant, Anti-lipoxygenase, Drug, Gallic acid, Galls, Plants, Terminalia chebula}, doi = {10.4103/0974-8490.171103}, author = {Ravi Shankara Birur Eshwarappa and Yarappa Lakshmikantha Ramachandra} } @article {653, title = {Extraction, Gas Chromatography-mass Spectrometry Analysis and Screening of Fruits of Terminalia Chebula Retz. for its Antimicrobial Potential}, journal = {Pharmacognosy Research}, volume = {5}, year = {2013}, month = {May 2013}, pages = {162-168}, type = {Original Article }, chapter = {162}, keywords = {Disc Diffusion Assay, Enterobacter Aerogenes, GC-MS, Kaempferol-3-O-rutinoside, Pyrogallol, Terminalia chebula}, doi = {10.4103/0974-8490.112421}, author = {Geeta Singh and Padma Kumar} }