@article {1501, title = {Network Pharmacology Approach to Determine the Molecular Mechanism of Chitraka (Plumbago zeylanica L.) in the Treatment of Obesity}, journal = {Pharmacognosy Research}, volume = {17}, year = {2025}, month = {September 2025}, pages = {1274-1280}, type = {Original Article}, chapter = {1274}, abstract = {

Background: The state of excessive bodily fat buildup is known as obesity (Sthoulya). Anti-obesity drugs in the market might cause adverse effects, for safer and more effective anti-obesity medications from plant-based sources becomes a top focus. In Ayurveda, Chitraka moola (Plumbago zeylanica L.) is a commonly used herb, because of its therapeutic effect. Network pharmacology is an area of drug discovery and development research by creating an opportunity for the methodical study of conventional treatments. This study highlights key phytochemicals, targets and signalling pathways of Chitraka for the treatment of obesity. Materials and Methods: This study assessed through biological databases, GeneCard, HPA databases, PPI Network Construction, KEGG pathway enrichment analysis, target-Compound-Pathway{\textquoteright} Network Construction and Molecular Docking Analysis. Results: Using the BindingDB and Uniprot databases, pinpointed 155 target genes with respect to these 28 active phytochemicals, Curated gene-disease data were extracted from the GeneCard and HPA databases based on the term obesity it was found that 26 out of the 28 drugs target exactly 137 disease targets linked to obesity, Using the String database, a PPI network was built. KEGG functional enrichment analysis to investigate the signalling pathways was carried out using SHINYGO database, Cytoscape was used to build the interaction relationship between 15 significantly enriched KEGG pathways, 137 intersecting targets and 26 core active ingredients, Molecular Docking visualises the binding pose with the highest docking score. Conclusion: This study emphasizes crucial mechanism, target and bioactive of Chitraka against obesity, indicating a strong pharmacological foundation for additional clinical research.

}, keywords = {Chitraka moola, Lupeol, Network pharmacology, Obesity, Plambago zeylanica, Sthoulya, β-sitosterol}, doi = {10.5530/pres.20252331}, author = {Prabhakar Basappa Hegade and Praveen Nagappa Bhirdi and Ajit Lingayat} } @article {1508, title = {Pharmacological Review of Anti-Obesity Herbs from Chakradatta: Insights and Mechanisms}, journal = {Pharmacognosy Research}, volume = {17}, year = {2025}, month = {September 2025}, pages = {1148-1162}, type = {Review Article}, chapter = {1148}, abstract = {

Background: Obesity has become a major global health crisis, significantly increasing the risk of Type 2 diabetes, cardiovascular diseases, and certain cancers, while placing a considerable economic burden on healthcare systems. Its prevalence has more than tripled between 1975 and 2022. With growing concerns over the side effects of synthetic anti-obesity drugs, traditional medicinal herbs are gaining attention for their safer and multi-targeted therapeutic potential. Aim: This review aims to evaluate the efficacy of Ayurvedic herbs in obesity management by examining their roles in modulating key molecular mechanisms associated with lipid metabolism. Materials and Methods: A systematic literature review was conducted focusing on anti-obesity herbs mentioned in the "Sthoulya" chapter of the classical Ayurvedic text Chakradatta. Databases such as PubMed were searched using keywords and MeSH terms including {\textquotedblleft}Ayurvedic herbs{\textquotedblright} and {\textquotedblleft}anti-obesity.{\textquotedblright} Studies published between 2007 and 2024 were screened for in vivo and in vitro evidence related to the mechanisms of action of these herbs. Clinical trials, case studies, and articles with methodological limitations were excluded. Results: This study explores the impact of 34 Ayurvedic herbs on lipid metabolism and their potential in managing obesity. The herbs evaluated include Embelia ribes, Hordeum vulgare, Phyllanthus emblica, Cyperus rotundus, Piper longum, Aegle marmelos, Premna Serratifolia, Terminalia bellirica, Terminalia chebula, Plumbago zeylanica, Adhatoda zeylanica, Ziziphus mauritiana, Acorus calamus, Alstonia scholaris, Aconitum heterophyllum, Azadirachta indica, Citrullus colocynthis, Saussurea lappa, Brassica campestris, Zingiber officinale, Curcuma longa, Commiphora wightii, Acacia catechu, Piper nigrum, Cuminum cyminum, Moringa oleifera, Picrorhiza kurroa, Coriandrum sativum, Mangifera indica, Punica granatum, Foeniculum vulgare, Tinospora cordifolia, Elettaria cardamomum, Juniperus communis. These herbs demonstrate a wide range of mechanisms in lipid metabolism regulation, such as inhibiting lipogenesis, enhancing lipolysis, regulating appetite, promoting thermogenesis, and improving fat oxidation. Their multi-targeted actions highlight their potential as effective natural agents in the management of obesity. Conclusion: Ayurvedic herbs offer promising multi-targeted approaches for managing obesity. Further scientific validation and clinical studies are essential to establish their efficacy and integrate them into modern therapeutic frameworks.

}, keywords = {Adipose tissues, Obesity, Pathways, Sthoulya}, doi = {10.5530/pres.20250135}, author = {Arushi Saroch and Giramalla Patil and Swapnil Yashwant Chaudhari and Pramod Yadav and Galib Ruknuddin and Pradeep Kumar Prajapati} }