@article {1530, title = {Stability Profiling of Gokshuradi Kashaya under Accelerated Conditions: An Analytical Study}, journal = {Pharmacognosy Research}, volume = {18}, year = {2026}, month = {November 2025}, pages = {1-5}, type = {Original Article}, chapter = {1}, abstract = {

Background: Gokshuradi Kashaya is a classical formulation mentioned in Sahasrayoga, which is widely used for its therapeutic benefits. Traditionally, the saviryata avadhi of Kashaya is considered to be less i.e. 3 hr, but modern pharmaceutical practices makes it necessary for a scientific evaluation of its stability. Objectives: To identify the stability of Gokshuradi kashaya by using accelerated stability study method. Materials and Methods: Gokshuradi Kashaya was prepared as per the standard classical procedure. Samples were stored under accelerated conditions (40{\textpm}2{\textordmasculine}C and 75{\textpm}5\% RH) for 6 months as per ICH Q1A (R2) guidelines. Stability study had 3 timepoints for assessments i.e. 0th month, 3rd month and 6 months. Parameters like organoleptic characters and microbial load and TLC profile was been assessed. Results: There was no significant changes observed in organoleptic characters. Slight reductions in pH and minor variations in total solids and viscosity were present but within acceptable limits. Microbial load showed reduced bacterial load and no fungal contamination during 6 months. There was no change observed in TLC profiles. Conclusion: Gokshuradi Kashaya was found to be stable in physicochemical, microbial load. These findings can provide a provisional shelf life of six months, it needs to be confirmed by long-term real-time stability studies.

}, keywords = {Accelerated stability study, Gokshuradi Kashaya, Microbial Load, TLC Profile.}, doi = {10.5530/pres.20260045}, author = {Rajashekhar Sanapeti V and Pradeep L Grampurohit and Dalal Dimple D} } @article {1481, title = {Accelerated Stability Study of Powder Formulation Safoof Muqliyasa and Safoof Mulayyin}, journal = {Pharmacognosy Research}, volume = {17}, year = {2025}, month = {September 2025}, pages = {1253-1273}, type = {Original Article}, chapter = {1253}, abstract = {

Background and Objectives: Evaluation of stability studies of Unani Medicine (UM) formulations determined on the basis of scientific data are the need of the time and also recommended in D and C Act. There is immense need to evaluate precise shelf life for each powder formulations. Materials and Methods: Accelerated Stability Study (ASS) of Safoof Muqliyasa (S. Muq) and Safoof Mulayyin. (S. Mul) was carried out with at elevated temperature and humidity conditions 40{\textordmasculine}C{\textpm}2{\textordmasculine}C with Relative Humidity of 75\%{\textpm}5\% RH according to ICH guidelines, by keeping in stability chamber in containers used by commercial UM. Pharmacy{\textquoteright}s (i.e. sealed HDPE containers). Testing frequency of samples was 0, 3 and 6 months and was subjected to various organoleptic, physical, microbiological and chemical tests parameters with HPLC quantification of active constituents/markers (Chebulic acid in S. Muq and Gingerol in S. Mul). Results were accessed as per API guidelines and are also statistically analyzed for 10\% degradation, from liner regression equation using individual slope and Intercept. Results: Both S. Muq and S. Mul were suitable at accelerated condition upto 3 month storage on selected physical, microbiological and chemical parameters as per API evaluation guidelines, and it can be extrapolated that real time shelf life period (predicted stability) according to Grimm{\textquoteright}s statement, for zone III and IV, 3.3 as 10 month at room temperature and packaging method adopted in the study and by 10\% degradation in different parameters by multiplying factor of 3.3 accelerated stability of Safoof Muqliyasa can be extrapoled as 2 years and 1 month and for Safoof Mulayyin 1 year and 5 months. Conclusion: According to physical and microbiological parameters both S. Muq and S. Mul are stable for 6 months in ASS but changes in selected chemical parameters was observed for after 3rd month making it stable approximately for 1 year. Stability of salt containing S. Mul was found to be comparatively lower than the non-salt containing S. Muq This observation/ shelf life may be exclusive to both the powders.

}, keywords = {Accelerated stability study, Powder, Safoof Mulayyin, Safoof Muqliyasa, Stability, Unani}, doi = {10.5530/pres.20252160}, author = {Md Naquibuddin and Hamiduddin and Gazi Jahangeer Rather and Fakeha Firdous Khanbhadur and Mohammed Saad} }