@article {1412,
	title = {Mechanistic Role of Phytophenolic Acids in the Management of Alzheimer{\textquoteright}s Disease: A Comprehensive Review},
	journal = {Pharmacognosy Research},
	volume = {17},
	year = {2025},
	month = {April 2025},
	pages = {1-11},
	type = {Review Article },
	chapter = {1},
	abstract = {<p class="rtejustify">Alzheimer{\textquoteright}s Disease (AD) or dementia, is a brain illness, which is chronic and non-reversible and is related to advanced memory loss, cognitive decline and altered behaviour. Current treatments including synthetic agents mostly have an effect of only providing relief to the patient without treating the root cause of disease. Though synthetic drugs available for the treatment but are only few and are associated side effects. A better alternate will be the traditionally used herbal drugs in the treatment of neurodegenerative diseases. Phenolic acids are secondary metabolites in plants and current evidence indicates that they can be useful in the treatment of AD because of their antioxidant, anti-inflammatory and neuroprotective. The present review explores the multifaceted functions of phenolic acid which include neutralizing Reacting Oxygen Species (ROS), preventing amyloid-beta aggregation, reducing hyperphosphorylation of tau protein and modulating neuro-inflammation. Several phenolic acids such as gallic acid, ellagic acid, caffeic acid, ferulic acid, coumaric acid, etc. Have demonstrated significant neuroprotective effects in various preclinical studies. The mode of action phenolic acids can be identified to produce better and more attuned treatments. Similarly, the synergistic effect exerted by phenolic acid when combined with other medical agents will enhance the potential efficacy of other drugs. In conclusion, the present review is an attempt at extensive and elaborated information regarding phytophenolic acids, with significant promise in fighting AD based on their antioxidant, anti-inflammatory and neuroprotective properties as a multi-faceted approach to the complex pathology in AD.</p>
},
	keywords = {Alzheimer{\textquoteright}s disease, Amyloid-beta, Cognitive decline, Neuroprotection, Phenolic acids, Tau protein},
	doi = {10.5530/pres.20250001},
	author = {Abhishek Pete Nagaraj and Annegowda Hardur Venkatappa and Jayashree Kallukombari Ramakrishna and Purushotham Karadigere Nagaraju and Bevinahalli Ramesh and Noor ul Eain}
}
@article {1391,
	title = {Unearthing the Modulatory Operations of Phytochemicals: A Reliable Framework for Therapeutic Approaches},
	journal = {Pharmacognosy Research},
	volume = {17},
	year = {2025},
	month = {April 2025},
	pages = {1-10},
	type = {Review Article},
	chapter = {1},
	abstract = {<p class="rtejustify">Phytochemicals in no small measure confer active roles in human survival as well as in the prevention of various diseases by their effortless ability to combat oxidative stress known to shorten life expectancy in humans. A number of these factors are well known to predispose an individual to ageing, senescence, microvascular and macrovascular diabetic complications, cardiovascular and neurological disorders. The incidence of cancer amelioration in this regard cannot be discountenanced. A vast array of identified factors that are deep rooted in the cause of diseases implicated in oxidative stress are but not limited to chemical and environmental contaminants in air, food and water while several lifestyle modifications including lack of exercise, smoking and dietary preferences are key factors implicated in disease developments. While we review the extant roles of fruits, vegetables, grains and seed oils as safe for consumption, owing to their astonishing medicinal attributes to counteract the menace of free oxidants in cells, the emphasis on plant-based diets especially the ones that contains phenolic acids and flavonoids with strong antioxidant capabilities cannot be more emphasized. Many of these therapeutic roles are possible by the excess mopping of reactive oxygen in the body thereby protecting cells from damage. The wondrous effects of these antioxidants in cells can be implied to reduce the risk of cardiovascular and neurological diseases such as diabetes mellitus, obesity, hypertension, arterosclerosis, Alzheimer{\textquoteright}s and long-term cancer.</p>
},
	keywords = {Cardiovascular, Flavonoids, Neurological disorders, Oxidative stress, Phenolic acids, Phytochemicals},
	doi = {10.5530/pres.20252043},
	author = {Ayodeji Benjamin Akawa and Isaac Adekola Adu and Ibrahim Abayomi Yekini and Ilesanmi Kayode Fasuba and Oluranti Esther Olaiya}
}
